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Auditory brainstem evoked responses in hyperlipidaemia: effect of various lipid fractions on auditory function

Published online by Cambridge University Press:  14 December 2011

J S Thakur ,
N K Mohindroo ,
M S Vasanthalakshmi ,
N Kashyap ,
R K Azad  and
D R Sharma
J S Thakur*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Indira Gandhi Medical College, Shimla, HP, India
N K Mohindroo
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Indira Gandhi Medical College, Shimla, HP, India
M S Vasanthalakshmi
Affiliation:
Department of Speech-Language Pathology, All India Institute of Speech and Hearing, Mysore, Karnataka, India
N Kashyap
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Indira Gandhi Medical College, Shimla, HP, India
R K Azad
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Indira Gandhi Medical College, Shimla, HP, India
D R Sharma
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Indira Gandhi Medical College, Shimla, HP, India
*
Address for correspondence: Dr J S Thakur, Department of Otolaryngology-Head and Neck Surgery, Indira Gandhi Medical College, Shimla 171001, India Fax: 91 177 2800224 E-mail: [email protected]
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Abstract

Objective:

To evaluate the effect of different lipid fractions on auditory brainstem evoked responses in hyperlipidaemia.

Method:

We conducted a single institution (medical college), prospective, cross-sectional study of 25 hyperlipidaemic patients and 25 normolipidaemic controls, all with a normal hearing threshold on pure tone audiometry. Brainstem evoked response audiometry results were recorded in both groups. The hyperlipidaemic group were further divided into two subgroups, based on the serum value of each lipid fraction: those with less than and those with greater than the mean serum value. These two subgroups were further compared with the control group.

Results:

The hyperlipidaemic and normolipidaemic groups had statistically significant differences for all audiometry waves apart from the wave I and the III–V interpeak latencies. The subgroups had a statistically significant difference in brainstem evoked responses. We found a statistically significant association between low-density lipoproteins and many waveforms in the hyperlipidaemic group.

Conclusion:

We found that low-density lipoproteins were significantly associated with many waveforms in hyperlipidaemic patients. Thus, low-density lipoproteins may be important in auditory dysfunction.

Keywords

Hearing Loss, SensorineuralEvoked Response, Auditory BrainstemCochleaHyperlipidaemia
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 3 , March 2012 , pp. 249 - 256
Copyright
Copyright © JLO (1984) Limited 2011

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References

1Axelsson, A, Lindgren, F. Is there a relationship between hypercholesterolaemia and noise-induced hearing loss? Acta Otolaryngol 1985;100:379–86Google Scholar
2Glueck, CJ. Classification and diagnosis of hyperlipoproteinemia. In: BM, Rifkind, RI, Levy, eds. Hyperlipidemia: Diagnosis and Therapy. New York: Grune and Stratton, 1977;17–39Google Scholar
3Dawber, TR, Moore, FE, Mann, GV. Coronary heart disease in the Framingham study. Am J Public Health 1957;47:4–28Google Scholar
4Kannel, WB, Dawber, TR, Kagan, A, Revotskie, N, Stokes, J. Factors of risk in the development of coronary heart disease: six year follow-up experience. The Framingham study. Ann Intern Med 1961;55:33–50CrossRefGoogle ScholarPubMed
5Suzuki, K, Kaneko, M, Murai, K. Influence of serum lipids on auditory function. Laryngoscope 2000;110:1736–8CrossRefGoogle ScholarPubMed
6National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143–421CrossRefGoogle Scholar
7Rosen, S, Olin, P, Rosen, HV. Dietary prevention of hearing loss. Acta Otolaryngol 1970;70:242–7Google Scholar
8Spencer, JT Jr.Hyperlipoproteinemias in the etiology of inner ear disease. Laryngoscope 1973;83:39–78CrossRefGoogle ScholarPubMed
9Morizono, T, Paparella, MM. Hypercholesterolemia and auditory dysfunction. Experimental studies. Ann Otol Rhinol Laryngol 1978;87:804–14CrossRefGoogle ScholarPubMed
10Saito, T, Sato, K, Saito, H. An experimental study of auditory dysfunction associated with hyperlipoproteinemia. Arch Otorhinolaryngol 1986;243:242–5CrossRefGoogle ScholarPubMed
11Hidaka, T. Scanning and transmission electron microscopic observations of the inner ear of hamsters with hyperlipidemia. Nihon Jibiinkoka Gakkai Kaiho 1997;100:900–8CrossRefGoogle ScholarPubMed
12Kashiwado, I, Hattori, Y, Qiao, Y. Functional and morphological changes in the cochlea of cholesterol fed guinea pigs. Nihon Ika Daigaku Igakkai Zasshi 1994;61:321–9CrossRefGoogle ScholarPubMed
13Satar, B, Özkaptan, Y, Sürücü, HS, Öztürk, H. Ultrastructural effects of hypercholesterolemia on the cochlea. Otol Neurotol 2001;22:786–9CrossRefGoogle ScholarPubMed
14Ben-David, Y, Pratt, H, Landman, L, Fradis, M, Podoshin, L, Yeshurun, D. A comparison of auditory brainstem evoked potentials in hyperlipidemic and normolipidemic subjects. Laryngoscope 1986;96:186–9Google Scholar