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Anti-neutrophil cytoplasmic antibody-associated mucocutaneous allergic vasculitis with oral manifestations caused by propylthiouracil

Published online by Cambridge University Press:  29 June 2007

M. M. Sorribes ,
N. R. Welinder  and
S.-E. Stangerup
M. M. Sorribes*
Affiliation:
Department of Otorhinolaryngology, Gentofte University Hospital, DK-2900 Hellerup, Denmark.
N. R. Welinder
Affiliation:
Department of Otorhinolaryngology, Gentofte University Hospital, DK-2900 Hellerup, Denmark.
S.-E. Stangerup
Affiliation:
Department of Otorhinolaryngology, Gentofte University Hospital, DK-2900 Hellerup, Denmark.
*
Address for correspondence: Michael M. Sorribes, The Department of Otorhinolaryngology, Hillerød Hospital, Dyrehavevej 2, DK-3400 Hillerød, Denmark. Fax: +45 48 29 38 11
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Abstract

A 49-year-old woman treated with increasing dosage of propylthiouracil (PTU) in order to control hyperthyroidism, developed progressive necrotic ulcers in the oral cavity, oropharynx and rhinopharynx and vasculitic ulcers on both auricular pinnae after a few days. The PTU treatment was immediately discontinued and the mucosal and skin manifestations resolved promptly. Laboratory findings, including anti-neutrophil cytoplasmic antibodies (ANCA), suggested allergic vasculitis. This is to our knowledge the first reported case of oral manifestations of PTU-induced allergic vasculitis.

Keywords

Vasculitis, allergic cutaneousOral ulcerDrug therapyAntibodies, antineutrophil cytoplasmic
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 5 , May 1999 , pp. 477 - 479
Copyright
Copyright © JLO (1984) Limited 1999

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