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Absence of Epstein-Barr virus encoded RNA and latent membrane protein (LMP1) in salivary gland neoplasms

Published online by Cambridge University Press:  29 June 2007

A. M. Pollock ,
M. Toner ,
M. McMenamin ,
J. Walker  and
C. I. Timon
A. M. Pollock*
Affiliation:
Department of Histopathology, St. James's Hospital, Dublin, Ireland
M. Toner
Affiliation:
Department of Histopathology, St. James's Hospital, Dublin, Ireland Department of Otolaryngology – Head and Neck Surgery, St. James's Hospital, Dublin, Ireland
M. McMenamin
Affiliation:
Department of Histopathology, St. James's Hospital, Dublin, Ireland
J. Walker
Affiliation:
Department of Histopathology, St. James's Hospital, Dublin, Ireland
C. I. Timon
Affiliation:
Department of Oral Surgery, Medicine and Pathology, Dublin Dental Hospital, Dublin, Ireland
*
Address for correspondence: Dr Anne Marie Pollock, Histopathology Department, Royal Victoria Infirmary, Queen Victoria Street, Newcastle-upon-Tyne NE1 4LP
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Abstract

A series of 55 (42 benign and 13 malignant) salivary gland tumours were investigated by immunohistochemistry, to detect Epstein-Barr virus (EBV) latent membrane protein (LMP1) and by in situ hybridization for EBV-encoded RNA. Non-neoplastic gland from all the patients with tumours and 15 control glands were also examined. All cases, both neoplastic and non-neoplastic were negative for LMP1 and failed to show any positive signal by in situ hybridization for EBV RNA. One undifferentiated carcinoma from a European patient was included in the group. These results confirm previous reports of an ethnic association between EBV and undifferentiated carcinomas of the salivary gland. They do not support an aetiological role for EBV in other salivary gland tumours.

Keywords

Herpesvirus 4, humanHybridizationSalivary glands
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 10 , October 1999 , pp. 906 - 908
Copyright
Copyright © JLO (1984) Limited 1999

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