Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-25T07:08:24.210Z Has data issue: false hasContentIssue false
  • English
  • Français

The use of zeolites as slow release anthelmintic carriers

Published online by Cambridge University Press:  12 April 2024

A. Dyer ,
S. Morgan ,
P. Wells  and
C. Williams
A. Dyer
Affiliation:
Department of Chemistry, University of Salford, Salford, Lancashire, M5 4WT, UK
S. Morgan
Affiliation:
Department of Chemistry, University of Salford, Salford, Lancashire, M5 4WT, UK
P. Wells
Affiliation:
Department of Chemistry, University of Salford, Salford, Lancashire, M5 4WT, UK
C. Williams*
Affiliation:
Department of Chemistry, University of Salford, Salford, Lancashire, M5 4WT, UK
*
*Address for correspondence: School of Applied Sciences, University of Wolverhampton, Wolverhampton, WV1 1SB, UK, Fax: 01902 322680 E-mail: [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

This work examines the ability of commerical zeolite Y to act as a slow release agent for a number of anthelmintic drugs. Administration to rats, dosed with Nippostrongylus brasiliensis, of pyrantel and/or fenbendazole and pigs, dosed with Ascaris and Oesophagostomum, of dichlorvos (DDVP) loaded onto zeolite Y was more sucessful in killing adult worms than administration of the pure drug alone. The zeolite Y was used as supplied for initial studies and then later dealuminated for further studies. The drug loadings were monitored by thermal analysis and the loaded zeolites were used in several field trials. The results indicate that zeolite Y is a suitable vehicle for the slow release of some anthelmintics. The slow release of drug from the zeolite matrix improved its efficacy.

Type
Research Article
Information
Journal of Helminthology , Volume 74 , Issue 2 , June 2000 , pp. 137 - 141
Copyright
Copyright © Cambridge University Press 2000

References

Dyer, A., Wells, P.D. & Williams, C.D. (1986) The use of zeolites as slow release agents for anthelmintic drugs. Patent: PCT. INT. APPL. WO 8705,504.Google Scholar
Jacobs, D.E. (1968) Experiences with a broad-spectrum anthelmintic, dichlorvos, in the adult pig. Veterinary Record 83, 160–164.Google Scholar
Kerr, G.T. (1968) Chemistry of crystalline aluminosilicates: preparation of aluminium deficient Faujasites. Journal of Physical Chemistry 72, 2594–2596.CrossRefGoogle Scholar
Mumpton, F.A. (1978) Natural zeolites: a new industrial mineral commodity. pp. 1–34 in Sand, L.B. & Mumpton, F.A. (Eds) Natural zeolites properties and uses. Oxford, Pergamon Press.Google Scholar
Mumpton, F.A. & Fishman, P.H. (1977) The application of natural zeolites in animal science and aquaculture. Journal of Animal Science 45, 1188–1203.CrossRefGoogle Scholar
Pond, W.G. (1984) Protection against acute ammonia toxicity by clinoptilolite in mature sheep. Nutritional Reports International 30, 991–1002.Google Scholar
Prichard, R.K., Henessy, D.R. & Steel, J.W. (1976) Prolonged adminstration: a new concept for increasing the spectrum and effectiveness of anthelmintics. Veterinary Parasitology 4, 309–315.CrossRefGoogle Scholar
Shaker, S.K., Dyer, A. & Storey, D.M. (1992) Treatment of Nippostrongylus brasiliensis in normal and SPF rats using tetramisole loaded into zeolite. Journal of Helminthology 66, 288–292.CrossRefGoogle ScholarPubMed
Wells, P.D. & McHugh, M. (1983) Effect of dietary zeolite on host and parasite in rats infected with the nematode, Nippostrongylus brasiliensis . Zeolites 4, 353–359.CrossRefGoogle Scholar