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Trace element levels in the liver of rats with acute and chronic fascioliasis and after treatment with zinc-copper hydroxochloride mixed crystals

Published online by Cambridge University Press:  12 April 2024

N.T. Tsocheva-Gaitandjieva ,
M.P. Gabrashanska  and
S. Tepavitcharova
N.T. Tsocheva-Gaitandjieva*
Affiliation:
Institute of Experimental Pathology and Parasitology, Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev St., Bl. 25, 1113 Sofia, Bulgaria
M.P. Gabrashanska
Affiliation:
Institute of Experimental Pathology and Parasitology, Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev St., Bl. 25, 1113 Sofia, Bulgaria
S. Tepavitcharova
Affiliation:
General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev St., Bl. 25, 1113 Sofia, Bulgaria
*
*Fax: +359 2 71 01 07 Email: [email protected]
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Abstract

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Quantities of trace elements including copper, zinc, cobalt, manganese and iron were investigated in the liver tissue of rats at the acute or chronic stages of fascioliasis following treatment with zinc-copper hydroxochloride mixed crystals. Oral dosing (with food) of zinc–copper mixed crystals to healthy rats increased zinc and copper levels in the liver and decreased the iron content compared with controls. Manganese and cobalt levels did not change significantly. Significant reductions in all trace elements except manganese occurred in the liver of rats with acute or chronic fascioliasis. Manganese levels were slightly increased in rats at the acute stage and slightly decreased in rats at the chronic stage of fascioliasis. The application of mixed zinc–copper crystals at the acute or chronic stages of fascioliasis lead to a restoration of zinc and copper levels and a slight reduction in the iron levels in liver tissue of rats. The beneficial effects of applied salts were more apparent in rats chronically infected with Fasciola hepatica.

Type
Review Article
Information
Journal of Helminthology , Volume 76 , Issue 1 , March 2002 , pp. 87 - 89
Copyright
Copyright © Cambridge University Press 2002

References

Davtyan, E.A. (1982) On trace elements-like factors enhancing host-parasite relationships during helminthoses and in the possibility for their application for raising at animal production. Biological Journal of Armenia 30(4), 2–5 (in Russian).Google Scholar
Damyanova, A. & Gabrashanska, M. (1988) Mineral contents of helminths and their hosts. I. Fasciola hepatica and tissues of Bos taurus. . Khelmintologiya 26, 3–9 (in Bulgarian).Google Scholar
Du, Z., Hemken, R.M., Jackson, J.A. & Trammell, D.S. (1996) Utilization of copper in copper proteinate, copper lysine, and cupric sulfate using the rats as an experimental model. Journal of Animal Sciences 74, 1657–1663.CrossRefGoogle ScholarPubMed
Fedosova, E. (1978) Dynamics of iron and cobalt content in some organs and tissues of white rats of different ages. pp. 181–184 in Trace elements in medicine. Zdorovya, Kiev (in Russian).Google Scholar
Gabrashanska, M. (1993) On the effect of copper salts (basic and neutral) during ascaridiosis on chicks. Comptes Rendus de l'Academie Bulgare des Sciences 46, 97–99.Google Scholar
Gabrashanska, M., Galvez-Morros, M. & Garcia-Martinez, O. (1993) Application of small doses copper salts (basic and neutral) to Ascaridia galli-infected chicks. Journal of Helminthology 67, 287–290.CrossRefGoogle ScholarPubMed
Gabrashanska, M., Teodorova, S., Galvez-Morros, M. & Garcia-Martinez, O. (1999a) A kinetic model for Ascaridia galli populations in chickens treated with mixed salts of copper and zinc. Journal of Helminthology 73, 45–50.CrossRefGoogle ScholarPubMed
Gabrashanska, M., Tepavitcharova, S., Balarew, C., Galvez-Morros, M.M. & Arambarri, P. (1999b) The effect of excess dietary manganese on uninfected and Ascaridia galli-infected chicks. Journal of Helminthology 73, 313–316.CrossRefGoogle ScholarPubMed
Galvez-Morros, M., Garcia-Martinez, O., Wright, A. & Southon, S. (1992) Bioavailability in the rat of zinc and iron from the basic salts Zn5822441132O. Food Chemistry 43, 377–381.CrossRefGoogle Scholar
Galvez-Morros, M., Gabrashanska, M. & Garcia-Martinez, O. (1995) Comparison of the effects of basic and neutral zinc salts on chickens infected with Ascaridia galli . Parasitology Research 56, 199–205.Google ScholarPubMed
Keen, C., Reinstein, N., Goudey-Lefevre, J., Lefevre, M., Lonnerdal, B., Schneeman, B. & Hurley, L. (1985) Effect of dietary copper and zinc levels on tissue copper, zinc and iron in male rats. Biological Trace Element Research 8, 123–136.CrossRefGoogle ScholarPubMed
Mansour, M.M., Francis, W.M. & Farid, Z. (1985) Prevalence of latent iron deficiency in patients with chronic S. mansoni infection. Tropical and Geographical Medicine 37, 124–128.Google ScholarPubMed
Markov, L. (1987) Synthesis and thermal decomposition of Me(II)-Co(II) hydroxonitrate mixed crystals with layer structure type (Me=Mg, Ni, Cu, Zn). PhD thesis, Bulgarian Academy of Sciences, Sofia, Bulgaria.Google Scholar
Nozdryuhina, L.R (1977) Biological role of trace elements in the constitution of animals and humans. Moscow, Nauka, 86–119 (in Russian)Google Scholar
Pienaar, J.G., Basson, P.A., du Plessis, J.L., Collins, H.W., Naude, T.W., Boyazoglu, P.A., Boomker, L., Reyers, F. & Pienaar, W.L. (1999) Experimental studies with Stronglyloides papillosus in goats. Onderstepoort Journal of Veterinary Research 66, 191–235.Google ScholarPubMed
Storey, M.L. & Greger, J.L. (1987) Iron, zinc and copper interactions: chronic versus acute responses of rats. Journal of Nutrition 177, 1434–1442.CrossRefGoogle Scholar
Tsocheva, N. (1986) Combined action of Fasciola hepatica infection and diethylnitrosamine intoxication on the rat liver. PhD thesis, Bulgarian Academy of Sciences, Sofia (in Bulgarian). Google Scholar
Tsocheva, N. & Gabrashanska, M. (1992) Trace element content of the rat liver after Fasciola hepatica infection and diethylnitrosamine intoxication. Comptes Rendus de l'Academie Bulgare des Sciences 45(9), 115–117.Google Scholar
Tsocheva, N., Kadiiska, M., Yanev, S., Poljakova-Krusteva, O., Krustev, L. & Stoychev, T. (1992a) Changes in some parameters of liver drug metabolism in Fasciola hepatica infected and diethylnitrosamine injected rats. Helminthologia 29, 39–42.Google Scholar
Tsocheva, N., Kadiiska, M., Yanev, S., Poljakova-Krusteva, O., Krustev, L. & Stoychev, T. (1992b) Combined effect of fascioliasis and diethylnitrosamine carcinogenesis on the activity of the rat liver monooxygenase system. Comparative Physiology and Biochemistry 101C, 475–479.Google Scholar
Vazquez, C., Galvez-Morros, M., Millan, P. & Garcia-Martinez, O. (1990) Hidroxicloruro de zinc versus sulfato en la sobre carga oral de zinc. Nutricion Clinica 10, 33–37.Google Scholar
Vazquez, C., Millan, P., Galvez-Morros, M. & Garcia-Martinez, O. (1991) Zinc serico y talla en una poblacion infantil de 5 a 15 anos. Nutricion Clinica, 158–163 Edition especial.Google Scholar
Yu, S. & Beynen, A.C. (1994) The combined effect of high iron and zinc intake on copper status in rats. Biological Trace Element Research 42(1), 71–79.CrossRefGoogle ScholarPubMed