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Toxocara sero-prevalence and its relationship with allergic asthma in asthmatic patients in north-eastern Iran

Published online by Cambridge University Press:  01 October 2018

A. Khozime ,
M. Mirsadraee  and
H. Borji Open the ORCID record for H. Borji [Opens in a new window]
A. Khozime
Affiliation:
Department of Pathobiology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Iran
M. Mirsadraee
Affiliation:
Department of Internal Medicine, Islamic Azad University, Mashhad Branch, Iran
H. Borji*
Affiliation:
Department of Pathobiology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Iran
*
Author for correspondence: H. Borji, E-mail: [email protected]
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Abstract

Toxocariasis is an important neglected tropical disease that has been suggested as a possible etiologic agent of asthma. The objective of the present study was to investigate possible significant association between Toxocara seroprevalence and asthma in a clinic-based case-control study. Blood samples were collected from human subjects aged 5–70 years, 50 of whom had signs of asthma and 50 of whom had no signs of asthma. Risk factors for asthma and Toxocara spp. infection were assessed by a questionnaire given to each patient. Blood samples were analysed to measure levels of anti-Toxocara spp. immunoglobulin G (IgG). Patients with bronchial asthma were observed to have higher Toxocara spp. seropositivity than that of the non-asthmatic controls (6 vs 2%, P = 0.47). The mean anti-Toxocara spp. antibody titre was not significantly higher in patients with bronchial asthma than in individuals without asthma (P = 0.395, 95% CI = 0.579–1.45). There was no significant difference in the mean age, sex, social class, exposure to smoking and presence of domestic dog or cat at home between the two groups (P ≥ 0.05). The presence of anti-Toxocara spp. IgG was statistically associated with higher blood eosinophils, but it was not associated with asthma (P ≥ 0.05). The observed relationship between exposure to Toxocara spp. infection and bronchial asthma in Iranian patients warrants further evaluation. An understanding of any potential influence on the pathogenesis of human asthma provides a potential avenue for prevention.

Keywords

asthmaELISAhumanToxocara
Type
Research Paper
Information
Journal of Helminthology , Volume 93 , Issue 6 , November 2019 , pp. 677 - 680
Copyright
Copyright © Cambridge University Press 2018 

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References

Berenji, F et al. (2015) Soil contamination with Toxocara spp. eggs in public parks of Mashhad and Khaf, north east of Iran. Iranian Journal of Parasitology 10, 286–289.Google Scholar
Berenji, F et al. (2016) Seroepidemiological study of toxocariasis in the owners of domestic cats and dogs in Mashhad, northeastern Iran. Iranian Journal of Parasitology 11, 265–268.Google Scholar
Borji, H et al. (2011) A survey on endoparasites and ectoparasites of stray cats from Mashhad (Iran) and association with risk factors. Journal of Parasitic Diseases 35, 202–206.Google Scholar
Buijs, J, Borsboom, G and Van Gemund, JJ (1994) Toxocara seroprevalence in 5-year-old elementary schoolchildren: relation with allergic asthma. American Journal Epidemiology 140, 839–847.Google Scholar
Cadore, PS et al. (2016) Toxocariasis and childhood asthma: a case-control study. Journal of Asthma 53, 601–606.Google Scholar
Caraballo, L (2018) The tropics, helminth infections and hygiene hypotheses. Expert Review of Clinical Immunology 14, 99–102.Google Scholar
Emamapour, SR, Borji, H and Nagibi, A (2015) An epidemiological survey on intestinal helminths of stray dogs in Mashhad, north-east of Iran. Journal of Parasitic Diseases 39, 266–271.Google Scholar
Fernando, D et al. (2009) Toxocara seropositivity in Sri Lankan children with asthma. Pediatrics International 51, 241–245.Google Scholar
Gonzalez-Quintela, A et al. (2006) Toxocara infection seroprevalence and its relationship with atopic features in a general adult population. International Archives of Allergy and Immunology 139, 317–324.Google Scholar
Holland, CV (2017) Knowledge gaps in the epidemiology of Toxocara: the enigma remains. Parasitology 144, 81–94.Google Scholar
Jõgi, NO et al. (2018) Zoonotic helminth exposure and risk of allergic diseases: a study of two generations in Norway. Clinical & Experimental Allergy 48, 66–77.Google Scholar
Kanobana, K et al. (2013) Toxocara seropositivity, atopy and asthma: a study in Cuban schoolchildren. Tropical Medicine & International Health 18, 403–406.Google Scholar
Kustimur, S et al. (2007) Toxocara seroprevalence in adults with bronchial asthma. Transactions of the Royal Society of Tropical Medicine and Hygiene 101, 270–274.Google Scholar
Lambrecht, BN and Hammad, H (2015) The immunology of asthma. Nature Immunology 16, 45–56.Google Scholar
Ma, G et al. (2018) Human toxocariasis. The Lancet Infectious Diseases 18, e14–e24.Google Scholar
Minvielle, MC et al. (1999) Asthma and covert toxocariasis. Medicina 59, 243–248.Google Scholar
Mosayebi, M et al. (2016) Detection of specific antibody reactivity to Toxocara larval excretory–secretory antigens in asthmatic patients (5–15 years). Open Microbiology Journal 10, 162–167.Google Scholar
Pinelli, E and Aranzamendi, C (2012) Toxocara infection and its association with allergic manifestations. Endocrine, Metabolic & Immune Disorders - Drug Targets 12, 33–44.Google Scholar
Pinelli, E et al. (2007) Infection with the roundworm Toxocara canis leads to exacerbation of experimental allergic airway inflammation. Clinical & Experimental Allergy 38, 649–658.Google Scholar
Rubinsky-Elefant, G et al. (2010) Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms. Annals of Tropical Medicine & Parasitology 104, 3–23.Google Scholar
Sharghi, N et al. (2001) Environmental exposure to Toxocara as a possible risk factor for asthma: a clinic-based case-control study. Clinical Infectious Diseases 32, 111–116.Google Scholar
Silva, MB et al. (2017) Risk factors for Toxocara spp. seroprevalence and its association with atopy and asthma phenotypes in school-age children in a small town and semi-rural areas of northeast Brazil. Acta Tropica 174, 158–164.Google Scholar
Zacharasiewicz, A et al. (2000) Toxocara and bronchial hyperactive reactivity results of a seroprevalence study. Wiener klinische Wochenschrift 112, 922–926.Google Scholar