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Studies with Brugia pahangi 7. Changes in lymphatics of injected cats

Published online by Cambridge University Press:  05 June 2009

Rosemary Rogers  and
D. A. Denham
D. A. Denham
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Stree, London WC1E7HT
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Abstract

Histological and gross changes in the lymphatics of cats singly or repeatedly infected with Brugia pahangi were studied chronologically over a period of 5 years. Lymphatic dilatation occurred within 2 weeks of injection and an initial acute inflammatory reaction in the lymphatic wall and lumen was followed by chronic inflammation within 4 months. In some long-term repeatedly infected cats, the lymphatics became non-functional fibrous cords and conditions of oedema and early elephantiasis, similar to those seen in early human filariasis, were produced. The main points of contention in the study of filariasis which were cluciaated in this system were: (1) that living worms cause lymphatic damage, not exacerbated by their death; (2) that lymphatic damage is not progressive after a certain peak of reaction is reached, except in repeatedly challenged animals; (3) that microfilariae do not appear to cause lymphatic damage.

Type
Research Article
Information
Journal of Helminthology , Volume 48 , Issue 3 , September 1974 , pp. 213 - 219
Copyright
Copyright © Cambridge University Press 1974

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References

REFERENCES

Bloom, W. and Fawcett, D. W. (1968) A textbook of Histology. 9th ed., W. B. Saunders&Co.: Philadelphia, London and Toronto.Google Scholar
Boggon, R. P. and Plafrey, A. J. (1969) Fine structure of human lymphatic trunks. Journal of Anatomy, 105, 192–194.Google Scholar
Burn, J. I. (1969) Obstructive lymphopathy. British Journal of Hospital Medicine, 2, 755–763.Google Scholar
Castellani, A. (1962) Elephantiasis nostra and elephantiasis tropica; a comparative study. Dermatologlca tropica, 1, 17–22.Google ScholarPubMed
Cohen, L. B., Nelson, G., Wood, A. M., Manson-Bahr, P. E. C. and Bowen, R. (1961) Lymphangiography in filarial lymphoedema and elephantiasis. American Journal of Tropical Medicine and Hygiene., 10, 843–848.CrossRefGoogle ScholarPubMed
Denham, D. A., Ponnudurai, T., Nelson, G. S., Rogers, Rosemary, and Guy, , Frances. (1972b) Studies with Brugia pahangi 11. The effect of repeated infection on parasite levels in cats. International Journal of Parasitology, 2, 401–407.CrossRefGoogle Scholar
Ewert, A., Balderach, R. and Elbihari, S. (1972) Lymphographic changes in regional lymphatics of cats infected with Brugia malayi. American Journal of Tropical Medicine and Hygiene., 21, 407–414.CrossRefGoogle ScholarPubMed
Frayley, E. E. and Weiss, L. (1961) An electron microscope study of the lymphatic vessels in the penile skin in the rat. American Journal of Anatomy, 109, 85–101.CrossRefGoogle Scholar
Galliard, H. (1968) Clinical, pathological and therapeutic aspects of bancroftian and Malayan filariasis. International Congress of Tropical Medicine and Malariology (8th); Teheran. Abstracts and Reviews, 95–96.Google Scholar
Gooneratne, B. W. M.Nelson, G. S., Denham, D. A., Furze, H. and Monson, E. (1971) Lymphographic changes in cats with filariasis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 65, 195–198.CrossRefGoogle ScholarPubMed
Hartz, P. H. (1944) Contribution to the histopathology of filariasis. American Journal of Clinical Pathology, 14, 34–43.CrossRefGoogle Scholar
Lane, C. (1948) Bancroftian filariasis—Biological mechanisms that underly its periodicity and other of its clinical manifestations. Transactions of the Royal Society of Tropical Medicine and Hygiene, 41, 717–784.Google ScholarPubMed
Leak, L. V. (1970) Electron microscopic observations on lymphatic capillaries and the structural components of the connective tissue—lymph interface. Microvascular Research, 2, 361–391.CrossRefGoogle ScholarPubMed
Nelson, G. S. (1966) The pathology of filarial infections. Helminthological Abstracts, 35, (4) 311–336.Google Scholar
O'connor, F. W. and Hulse, C. R. (1932) Some pathological changes associated with Wuchereria (Filaria) bancrofti infection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 25, 445–454.CrossRefGoogle Scholar
Pfleger, L. (1964) Histology and histopathology of cutaneous lymph vessels of the lower extremities. I. Morphology of cutaneous lymph vessels. II. Pathology of cutaneous lymph vessels. Archiv für Klinishe und Experimented Dermatologie, 221, 1–22, 23–58.CrossRefGoogle Scholar
Reddy, D. B. and Ray, J. C. (1963) Observations on tissue reactions in filariasis with particular reference to histopathological changes in the lymph glands. Journal of the Indian Medical Association, 41, 53–61.Google ScholarPubMed
Rogers, Rosemary, Denham, D. A., Nelson, G. S., Guy, Frances, and Ponnudurai, T. (1974) Studies with Brugia pahangi 3. Histological changes in the affected lymph nodes of infected cats. Annals of Tropical Medicine and Parasitology, in Press.CrossRefGoogle Scholar
Schacher, J. F. and Sahyoun, P. F. (1967) A chronological study of the histopathology of filarial disease in cats and dogs caused by Brugia pahangi (Buckley and Edeson, 1956). Transactions of the Royal Society of Tropical Medicine and Hygiene, 61, 234–243.CrossRefGoogle ScholarPubMed
Schacher, J. F., Sulahain, Annie, and Edeson, J. F. B. (1969) Experimental lymphoedema in dogs infected with Brugia spp. Transactions of the Royal Society of Tropical Medicine and Hygiene, 63, 682–683.CrossRefGoogle ScholarPubMed
Schacher, J. F. and Sulahain, A. (1972) Lymphatic drainage patterns and experimental filariasis in dogs. Annals of Tropical Medicine and Parasitology, 66, 209–217.CrossRefGoogle ScholarPubMed
Schacher, J. F., Edeson, J. F. B., Sulahain, A. and Rizk, G. (1973) An 18-month longitudinal Iymphographic study of filarial disease in dogs infected with Brugia pahangi (Buckley and Edeson,1956). Annals of Tropical Medicine and Parasitology, 67, 81–94.CrossRefGoogle ScholarPubMed
Wartman, W. B. (1944) Lesions of the lymphatic system in early filariasis. American Journal of Tropical Medicine, 24, 299–313.Google Scholar
Wartman, W. B. (1947) Filariasis in American Armed Forces in World War II. Medicine, 26, 333–394CrossRefGoogle ScholarPubMed