Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-26T02:58:26.705Z Has data issue: false hasContentIssue false
  • English
  • Français

Studies on Brugia pahangi. 13. The anthelmintic effect of compounds F151 (Friedheim), HOE 33258 (Hoechst) and their reaction product

Published online by Cambridge University Press:  05 June 2009

D. A. Denham ,
R. R. Suswillo ,
Rosemary Rogers ,
P. B. McGreevy  and
B. J. Andrews
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT
R. R. Suswillo
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT
Rosemary Rogers
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT
P. B. McGreevy
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT
B. J. Andrews
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT
Get access Rights & Permissions [Opens in a new window]

Abstract

F151 was a potent filaricide against adult Brugia pahangi in cats and jirds.

HOE 33258 did not kill adult worms in cats but had a marginal effect on adult worms in the peritoneal cavity of jirds. It was not immediately microfilaricidal in cats but the microfilarial counts of treated cats fell within a few weeks of treatment.

The reaction product, or mixture, of these two compounds (V5851 = E) was strongly macrofilaricidal m cats and jirds.

Type
Research Article
Information
Journal of Helminthology , Volume 50 , Issue 4 , December 1976 , pp. 243 - 250
Copyright
Copyright © Cambridge University Press 1976

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Denham, D. A. and Mcgreevy, P. B. (1976) Brugian Filariasis: A review of cpidemiological and experimental studies. Advances in Parasitology, 15, (in press).Google Scholar
Denham, D. A. and Mellor, P. (1976) The anthelmintic effects of a new compound “E” (Friedheim) on Onchocerca gutturosa in the cow—a possible tertiary screening system for drug action against O. volvulus in man. Journal of Hclminthology, 50,49–52.CrossRefGoogle ScholarPubMed
Denham, D. A., Ponnudurai, T., Nelson, G. S., Guy, F. and Rogers, R. (1971) The effect of Metrifonate on Brugia pahangi infections in domestic cats. Bulletin of the World Health Organization, 45, 423–429.Google ScholarPubMed
Denham, D. A. and Rogers, R. (1975) Structural and functional studies on the lymphatics of cats infected with Brugia pahangi. Transactions of the Royal Society of Tropical Medicine and Hygiene, 69, 173–176.CrossRefGoogle ScholarPubMed
Düwel, D. (1973) Studies in rodents and dogs with a new macro- and microfilaricidal compound. Abstracts R of the Ninth International Congress on Tropical Medicine and Malaria, 2,117.Google Scholar
Edeson, J. F. B. and Laing, A. B. G. (1959) Studies on filariasis in Malaya: The effect of diethylcarbamazine on Brugia malayi and Brugia pahangi in domestic cats. Annals of Tropical Medicine and Parasitology, 53, 394–399.Google Scholar
Friedheim, E. A. H. (1974) Therapeutic field trial of a macro- and microfilaricidal agent in canine filariasis. Bulletin of the World Health Organization, 50, 572–574.Google ScholarPubMed
Lämmler, G. and Grüner, D. (1975) Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 6.The filaricidal activity of organophosphorus compounds. Tropenmedizin und Parasitologie, 26, 359–369.Google Scholar
Lämmler, G., Herzog, H., Saupe, E. and Schutze, H. R., (1971) Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 2. The activity of drugs against microfilariae. Bulletin of the World Health Organization, 44, 757–763.Google Scholar
Rogers, R. and Denham, D. A. (1976) Studies with Brugia pahangi. 13.The activity of Levamisole. Journal of Helminthology, 50, 21–28.CrossRefGoogle Scholar
Santiago-Stevenson, D., Oliver-Gonzalez, J. and Hewitt, R. I. (1947) Treatment of filariasis bancrofti with l-diethyl-carbamyl-4-methylpiperazine hydrochloride (“hetrazan”). Journal of the American Medical Association, 135, 708–712.CrossRefGoogle ScholarPubMed
Suswillo, R. R. and Denham, D. A. (1977) A new system of testing for filaricidal activity using transplanted adult Brugia in the jird. Journal of Parasitology, 63, (in press).CrossRefGoogle ScholarPubMed
Wilson, T. (1950) Hetrazan in the treatment of filariasis due to Wuchereria malayi. Transactions of the Royal Society of Tropical Medicine and Hygiene, 44, 49–66.CrossRefGoogle ScholarPubMed