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Scanning electron microscope studies of the mucosa of rats infected with Hymenolepis dimlnuta (Cestoda)

Published online by Cambridge University Press:  18 November 2009

Jean Martin  and
Celia Holland
Jean Martin
Affiliation:
Molteno Institut, Downing Street, Cambridge CB2 3EE, UK
Celia Holland
Affiliation:
Molteno Institut, Downing Street, Cambridge CB2 3EE, UK
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Abstract

The intestinal morphology or rats given one, 10 or 100 cysticercoids of Hymenolepis diminuta was examined by scanning electron microscopy. The presence of this tapeworm causes extensive villous atrophy and fusion. The most extreme changes in mucosal architecture were observed adjacent to the mature proglottides of the worm and in these areas the villi were reduced either to flattened plate-like structures or to low irregularly shaped undulations. The presence of one large H. diminuta resulted in more severe pathological damage than caused by several smaller worms. Colonization of the upper region of the ileum by long filamentous bacteria was also observed in rats infected with H. diminuta.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 2 , June 1984 , pp. 93 - 99
Copyright
Copyright © Cambridge University Press 1984

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References

REFERENCES

Ali-khan, Z. (1978) Cellular changes in the lymphoreticular tissues of C57L/J mice infected with Echinococcus multilocularis cysts. Immunology, 34, 831–839.Google ScholarPubMed
Barker, I.K. (1973) Scanning electron microscopy of the duodenal mucosa of lambs infected with Trichostrongylus colubriformis. Parasitology, 67, 307–314.CrossRefGoogle ScholarPubMed
Barker, I.K. (1975a) Intestinal pathology associated with Trichostrongylus colubriformis infection in sheep: histology. Parasitology, 70, 165–171.CrossRefGoogle ScholarPubMed
Barker, I.K. (1975b) Intestinal pathology associated with Trichostrongylus colubriformis in sheep: vascular permeability and ultrastructure of the mucosa. Parasitology, 70, 173–180.CrossRefGoogle ScholarPubMed
Belding, D.L. (1958) In: Basic Clinical Parasitology. Appleton-Century-Crofts Inc.: New York.Google Scholar
Bonsdorff Von, B. (1977) Diphyllobothriasis in Man. Academic Press: London, New York, San Francisco.Google Scholar
Chase, D.G. & Erlandsen, S.L. (1976) Evidence of a complex life cycle and endospore formation in the attached filamentous, segmented bacteria from murine ileum. Journal of Bacteriology, 127, 572–583.CrossRefGoogle ScholarPubMed
Chowdhury, M.A.W., Khan, A.K.A. & Islam, K.M.N. (1981) Jejunal mucosa in Ascariasis. Proceedings of the First National Seminar on Integrated Family Planning, Nutrition and Parasite Control, Dhaka, pp. 27–38.Google Scholar
Coop, R.L., Anuus, K.W. & Mapes, C.J. (1973) Effect of large doses ot Nematodirus battus on the histology and biochemistry of the small intestine of lambs. International Journalfor Parasitology, 3, 340–361.Google Scholar
Coop, R.L. & Angus, K.W. (1975) The effect of continuous doses of Trichostrongylus colubriformis larvae on the intestinal mucosa of sheep and on liver vitamin A concentrations. Parasitology, 70, 1–9.CrossRefGoogle Scholar
D'alessandro, A., Ravsch, R.L., Cuello, C. & Aristizabal, N. (1979) Echinococcus vogeli in man, with a review of polycystic hydatid disease in Colombia and neighbouring countries. American Journal of Tropical Medicine and Hygiene, 28, 303–317.CrossRefGoogle Scholar
Erlandsen, S.L. & Chase, D.G. (1974) Morphological alterations in the microvillous border of villous epithelial cells produced by microorganisms. American Journal of Clinical Nutrition, 27, 1277–1286.CrossRefGoogle ScholarPubMed
Ferguson, A. & Jarrett, E.E.E. (1975). Hypersensitivity reactions of the small intestine: thymus independent reactions of experimental ‘partial villous atrophy’. Gut, 16, 114–117.CrossRefGoogle Scholar
Hindsbo, O., Andreassen, J. & Ruitenberg, J. (1982). Immunological and histopathological reactions of the rat against the tapeworm Hymenolepis diminuta and the effects of anti-thymocyte serum. Parasite Immunology, 4, 59–76.CrossRefGoogle ScholarPubMed
Martin, J. (1980) Scanning electron microscope studies of the small intestine of rats maintained on a low protein diet and infected with Nippostrongylus brasiliensis. Parasitology, 80, 39–47.CrossRefGoogle ScholarPubMed
Martin, J. & Lee, D.L. (1980) Nematodirus battus: scanning electron microscope studies of the duodenal mucosa of infected lambs. Parasitology, 81, 573–578.CrossRefGoogle ScholarPubMed
Mettrick, D.F. (1971) Hymenolepis diminuta: The microbial fauna, nutritional gradients and physicochemical characteristics of the small intestine of uninfected and parasitised rats. Canadian Journal of Physiology and Pharmacology, 49, 972–984.CrossRefGoogle Scholar
Mettrick, D.F. & Jackson, J.A. (1979) Vitamin absorption in the in vivo intestine of normal and infected Hymenolepis diminuta (Cestoda) rats. Journal of Helminthology, 53, 213–222.CrossRefGoogle ScholarPubMed
Olson, L.J. & Richardson, J.A. (1968) Intestinal malabsorption of D-glucose in mice infected with Trichinella spiralis. Journal of Parasitology, 54, 445–451.CrossRefGoogle ScholarPubMed
Pappas, P.W. (1976) Hymenolepis microstoma: Correlation of histopathology, host responses and organ hypertrophy. Experimental Parasitology, 40, 320–329.CrossRefGoogle ScholarPubMed
Pappas, P.W. & Schroeder, L.L. (1977) Biliary and intestinal pathology in mice infected with Hymenolepis microstoma as determined by scanning electron microscopy. Journal of Parasitology, 63, 762–764.CrossRefGoogle ScholarPubMed
Podesta, R.B. & Mettrick, D.F. (1974a) The effect of bicarbonate and acidification on water and electrolyte absorption by the intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats. American Journal of Digestive Diseases, 19, 725–735.CrossRefGoogle ScholarPubMed
Podesta, R.B. & Mettrick, D.F. (1974b) Pathophysiology of cestode infections: Effect of Hymenolepis diminuta on oxygen tensions, pH and gastrointestinal function. International Journal for Parasitology, 4, 277–292.CrossRefGoogle ScholarPubMed
Podesta, R.B. & Mettrick, D.F. (1977) Permeability changes in the parasitised (Hymenolepis diminuta: Cestoda) rat intestine. Comparative Biochemistry and Physiology, 57A, 265–273.CrossRefGoogle Scholar
Pout, D.D. (1970) The mucosal surface patterns of the small intestine of grazing lambs. British Veterinary Journal, 126, 357–363.CrossRefGoogle Scholar
Presidente, P.J.A. (1979) Liver lesions in the common wombat associated with migrating Taenia hydatigena larvae. International Journal for Parasitology, 9, 351–355.CrossRefGoogle Scholar
Shayo, M.E. & Benz, G.W. (1979) Histopathologic and histochemic changes in the small intestine of calves infected with Trichostrongylus colubriformis. Veterinary Parasitology, 5, 353–364.CrossRefGoogle Scholar
Smyth, J.D. (1976) In: Introduction to Animal Parasitology. Hodder & Stoughton: London, Sydney, Auckland, Toronto.Google Scholar
Spencer, H. (1973) In: Tropical Pathology. Springer-Verlag: Berlin, Heidelberg, New York.CrossRefGoogle Scholar
Symons, L.E.A. (1976) Scanning electron microscopy of the jejunum of the rat infected by the nematode Nippostrongylus brasiliensis. International Journal for Parasitology, 6, 107–111.CrossRefGoogle ScholarPubMed
Tannouk, G.W. & Savage, D.C. (1974) Influences of dietary and environmental stress on microbial populations in the murine gastro intestinal tract. Infection and Immunity, 9, 591–598.CrossRefGoogle Scholar
Taylor, S.M. & Pearson, G.R. (1979) Trichostrongylus vitrinus in sheep II. The location of nematodes and associated pathological changes in the small intestine during clinical infection. Journal of Comparative Pathology, 89, 405–412.CrossRefGoogle ScholarPubMed
Wells, P.D. (1962) Mast cell, eosinophil and histamine levels in Nippostrongylus brasiliensis infected rats. Experimental Parasitology, 12, 82–101.CrossRefGoogle ScholarPubMed
Willms, K. & Merchant, M.T. (1980) The inflammatory reaction surrounding Taenia solium larvae in pig muscle; ultrastructural and light microscopic observations. Parasite Immunology, 2, 261–275.CrossRefGoogle ScholarPubMed