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The response of nematodes in vivo and in vitro to some anthelmintics

Published online by Cambridge University Press:  05 June 2009

G. C. Coles
Affiliation:
Imperial Chemical Industries Ltd., Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire, SK10 4TG
R. M. McNeillie
Affiliation:
Imperial Chemical Industries Ltd., Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire, SK10 4TG

Abstract

Dietary feeding of drugs for 5 days to mice infected with Nematospiroides dubius and Hymenolepis nana detected all modern anthelmintics examined except stilbazium. A simple test using eggs of Nematodirus spathiger and adult Nippostrongylus brasiliensis to detect anthelmintics in vitro is reported.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1977

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References

REFERENCES

Brody, G. and Elward, T. E. (1971) Comparative activity of 29 known anthelmintics under standardized drug-diet and gavage medication regimes against four helminth species in mice. Journal of Parasitology, 57, 10681077.CrossRefGoogle Scholar
Coles, G. C. (1975) The response of Schistosoma mansoni maintained in vitro to schistosomicidal compounds. Journal of Helminthology, 49, 205209.CrossRefGoogle ScholarPubMed
Coles, G. C., East, J. M. and Jenkins, S. N. (1974) The mode of action of four anthelmintics. Experientia, 30, 1266.CrossRefGoogle ScholarPubMed
Coles, G. C., East, J. M. and Jenkins, S. N. (1975) The mechanism of action of the anthelmintic levamisole. General Pharmacology, 6, 309313.CrossRefGoogle Scholar
Coles, G. C. and Simpkin, K. G. (1977) Resistance of nematode eggs to the ovicidal activity of benzimidazoles. Research in Veterinary Science, 22, 386387.CrossRefGoogle Scholar
Egerton, J. R. (1969) The ovicidal and larvicidal effect of thiabendazole on various helminth species. Texas Reports on Biology and Medicine, 27, Supplement 2, 561580.Google ScholarPubMed
Kundle, D. W. and Theodorides, V. J. (1971) Activity of parbendazole against cestodes in mice. Journal of Parasitology, 57, 319.Google Scholar
Leland, S. E. (1967) In vitro cultivation of Cooperia punctata from egg to egg. Journal of Parasitology, 53, 10571060.CrossRefGoogle ScholarPubMed
Leland, S. E., Ridley, R. K., Slonka, G. F. and Zimmerman, G. L. (1975) Detection of activity for various anthelmintics against in vitro produced Cooperia punctata. American Journal of Veterinary Research, 36, 449456.Google ScholarPubMed
Roberts, L. S. and Fairbairn, D. (1965) Metabolic studies on adult Nippostrongylus brasilliensis (Nematoda: trichostrongyloidea). Journal of Parasitology, 51, 129138.CrossRefGoogle Scholar
Selling, H. A., Vonk, J. W. and Kaars Sijpesteijn, A. (1970). Transformation of the systemic fungicide methyl thiophanate into 2-benzimidazole carbamic acid methyl ester. Chemistry and Industry, 1970, 1625.Google Scholar
Theodorides, V. J. (1976). Anthelmintics: from laboratory animals to the target species. In Chemotherapy of Infectious Disease. Gadebusch, H. H. (ed). CRC Press Inc: Cleveland.Google Scholar
Tiner, J. D. (1958) A preliminary in vitro test for anthelmintic activity. Experimental Parasitology, 7, 292305.CrossRefGoogle ScholarPubMed