Hostname: page-component-745bb68f8f-s22k5 Total loading time: 0 Render date: 2025-01-18T19:50:42.899Z Has data issue: false hasContentIssue false
  • English
  • Français

Regulatory role of adrenergic neurotransmitters on the spontaneous muscular activity in the ruminant trematode Paramphistomum cervi (Paramphistomatidae)

Published online by Cambridge University Press:  31 May 2013

B. Saikia ,
C.C. Barua ,
S. Hazarika ,
L.C. Lahon ,
D. Saikia ,
R.S. Borah  and
P.K Verma
B. Saikia
Affiliation:
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
C.C. Barua*
Affiliation:
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
S. Hazarika
Affiliation:
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
L.C. Lahon
Affiliation:
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
D. Saikia
Affiliation:
Department of Animal Biotechnology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
R.S. Borah
Affiliation:
Department of Livestock Production and Management, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
P.K Verma
Affiliation:
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, SKAUST, R.S. Pura, Jammu, India
*
*Fax: 91-361-2337700 E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

The neuromuscular system of helminths is an important area for target identification and drug development. Many anthelmintics, namely ivermectin, levamisole, piperazine, pyrantel, praziquantel and organophosphates, produce paralysis of helminths by affecting their neuromuscular systems. The neuromuscular system of helminths is also an important area of research to identify some of the important differences between the neuromuscular physiology of helminths and mammals. The identification of differences would help in developing newer target-specific, safe and effective anthelmintics. The present study was carried out to investigate the effects of different adrenergic neurotransmitters (epinephrine, norepinephrine, dopamine, l-dopa) and their antagonists (propranolol and haloperidol) on the spontaneous muscular activity of isometrically mounted Paramphistomum cervi.

Type
Research Papers
Information
Journal of Helminthology , Volume 88 , Issue 3 , September 2014 , pp. 357 - 361
Copyright
Copyright © Cambridge University Press 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abidi, S.M.A. & Nizami, W.A. (2000) Monoamine oxidase in amphistomes and its role in worm motility. Journal of Helminthology 74, 283–288.Google Scholar
Ahmed, M. & Nizami, W.A. (1990) In vitro effect of some anthelmintics on the motility of Gigantocotyle explanatum . Japanese Journal of Parasitology 39, 529–534.Google Scholar
Bennett, J.L. & Gianutsos, G. (1977) Distribution of catecholamines in immature F. hepatica – a histochemical and biochemical study. International Journal of Parasitology 7, 221–225.CrossRefGoogle Scholar
Blair, K.L. & Anderson, P.A.V. (1994) Physiological and pharmacological properties of muscle cells isolated from the flatworm, Bdelloura candida (Tricladia). Parasitology 109, 325–335.Google Scholar
Bylund, D.B. (1994) Nomenclature of adrenoceptors. Pharmacological Review 46, 121–136.Google ScholarPubMed
Cully, D.L., Chen, G.T., Miller, C., Wing, T., Bennet, J.L. & Pax, R.A. (1996) Cholinergic inhibition of muscle fibres isolated from Schistosoma mansoni . Parasitology 108, 425–432.Google Scholar
Fairweather, I., Holmes, S.D. & Threadgold, L.T. (1983) Fasciola hepatica, a technique for monitoring in vitro activity. Experimental Parasitology 56, 369–380.CrossRefGoogle Scholar
Geary, T.G., Klein, R.D., Vanover, L., Bowman, J.W. & Tompson, D.P. (1992) The nervous system of helminths as target for drugs. Journal of Parasitology 78, 215–230.Google Scholar
Gustafsson, M.K.S. (1987) Immunocytochemical demonstration of macropeptides and serotonin in the nervous system of adult Schistosoma mansoni . Parasitological Research 74, 168–174.CrossRefGoogle Scholar
Harrow, I.D. & Gration, K.A.F. (1985) Mode of action of anthelmintics morantel, pyrantel and levamisole in the muscle cell membrane of the nematode Ascaris suum . Pesticide Science 16, 662–672.Google Scholar
Holmes, S.D. & Fairweather, I. (1984) Fasciola hepatica: the effects of neuropharmacological agents upon in vitro activity. Experimental Parasitology 58, 144–208.Google Scholar
Jackson, F. & Coop, R.L. (2000) The development of anthelmintic resistance in sheep nematodes. Parasitology 120, 95–107.CrossRefGoogle ScholarPubMed
Kumar, D. & Tripathi, H.C. (1996) Effect of nicotine and nicotinic antagonists on in vitro motility of Fasciola gigantica . Prospects of Livestock and Poultry Development in the 21st Century, 23–24 February. p. 29. Izatnagar, India, Central Avian Research Institute.Google Scholar
Martin, G.R. & Humphrey, P.P.A. (1994) Receptors for 5-hydroxytryptamine: current perspectives on classification and nomenclature. Neuropharmacology 33, 261–273.Google Scholar
Maule, A.G., Halton, D.W., Johnston, C.F., Show, C. & Fairweather, I. (1990) Serotonergic, cholinergic and peptidergic components of the nervous system in the monogenean parasite, Diclidophora merlangi: a cytochemical study. Parasitology 100, 255–273.CrossRefGoogle Scholar
Mellin, T.N., Busch, R.D., Wang, C.C. & Kath, G. (1983) Neuropharmacology of the parasitic trematode Schistosoma mansoni . American Journal Tropical Medicine Hygiene 32, 83–93.CrossRefGoogle ScholarPubMed
Pax, R.A., Siefker, C. & Bennett, J.L. (1984) Schistosoma mansoni: differences in acetylcholine, dopamine and serotonin control of circular and longitudinal parasite muscle. Experimental Parasitology 58, 314–324.CrossRefGoogle Scholar
Prichard, R.K. (2005) Is anthelmintic resistance a concern for heart worm control? What can we learn from the human filariasis control programs? Veterinary Parasitology 133, 243–253.CrossRefGoogle ScholarPubMed
Robertson, E.L. (1982) Chemotherapy of parasitic disease. pp. 797–802 in Booth, N.H. & McDonald, L.E. (Eds) Veterinary pharmacology and therapeutics. Ames, Iowa State University Press.Google Scholar
Snedecor, G.W. & Cochran, W.J. (1989) Statistical methods. 61 pp. Bombay, Oxford IBH.Google Scholar
Tripathi, H.C., Kumar, D., Chandra, S. & Prasad, A. (2000) Final report of the project entitled ‘Neurobiological studies in mature and immature Fasciola gigantica’ . Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh.Google Scholar
Verma, P.K., Katoch, R., Srivastava, A.K. & Pankaj, N.K. (2007) An overview of neurotransmitters of helminthic parasites. Veterinary Practitioner 8, 176–179.Google Scholar
Verma, P.K., Kumar, D. & Tandan, S.K. (2009) Functional role of cholinergic drugs on spontaneous muscular activity in the amphistome Gastrothylax crumenifer from ruminants. Journal of Helminthlogy 83, 77–82.Google Scholar
Verma, P.K., Kumar, D. & Tandon, S.K. (2010) In vitro effects of adrenergic neurotransmitter on spontaneous muscular activity of Gastrothylax crumenifer . Journal of Veterinary Parasitology 24, 25–31.Google Scholar