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Regulatory role of adrenergic neurotransmitters on the spontaneous muscular activity in the ruminant trematode Paramphistomum cervi (Paramphistomatidae)

Published online by Cambridge University Press:  31 May 2013

B. Saikia ,
C.C. Barua ,
S. Hazarika ,
L.C. Lahon ,
D. Saikia ,
R.S. Borah  and
P.K Verma
B. Saikia
Affiliation:
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
C.C. Barua*
Affiliation:
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
S. Hazarika
Affiliation:
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
L.C. Lahon
Affiliation:
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
D. Saikia
Affiliation:
Department of Animal Biotechnology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
R.S. Borah
Affiliation:
Department of Livestock Production and Management, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati781022, India
P.K Verma
Affiliation:
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, SKAUST, R.S. Pura, Jammu, India
*
*Fax: 91-361-2337700 E-mail: [email protected]
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Abstract

The neuromuscular system of helminths is an important area for target identification and drug development. Many anthelmintics, namely ivermectin, levamisole, piperazine, pyrantel, praziquantel and organophosphates, produce paralysis of helminths by affecting their neuromuscular systems. The neuromuscular system of helminths is also an important area of research to identify some of the important differences between the neuromuscular physiology of helminths and mammals. The identification of differences would help in developing newer target-specific, safe and effective anthelmintics. The present study was carried out to investigate the effects of different adrenergic neurotransmitters (epinephrine, norepinephrine, dopamine, l-dopa) and their antagonists (propranolol and haloperidol) on the spontaneous muscular activity of isometrically mounted Paramphistomum cervi.

Type
Research Papers
Information
Journal of Helminthology , Volume 88 , Issue 3 , September 2014 , pp. 357 - 361
Copyright
Copyright © Cambridge University Press 2013 

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