Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-05T05:12:07.989Z Has data issue: false hasContentIssue false
  • English
  • Français

Pulmonary superoxide dismutase activity in the mouse infected with Ancylostoma caninum larvae

Published online by Cambridge University Press:  05 June 2009

A. B. Kulkarni ,
M. K. Bhopale  and
K. D. Sharma
A. B. Kulkarni
Affiliation:
Departments of Biochemistry and Zoonosis, Haffkine Institute, Parel, Bombay 400 012, India
M. K. Bhopale
Affiliation:
Departments of Biochemistry and Zoonosis, Haffkine Institute, Parel, Bombay 400 012, India
K. D. Sharma
Affiliation:
Departments of Biochemistry and Zoonosis, Haffkine Institute, Parel, Bombay 400 012, India
Get access Rights & Permissions [Opens in a new window]

Abstract

Albino mice were infected per os with 1000 infective larvae of Ancylostoma caninum and pulmonary superoxide dismutase activity was studied after completion of lung migration. The total superoxide dismutase activity per mg of lung protein was elevated by 15% in infected mice. Of the two forms of superoxide dismutases studied, that containing Cu-Zn was elevated by 44%. this suggests that A. caninum in mice may result in histopathological changes leading to transient pulmonary oxygen toxicity.

Type
Research Note
Information
Journal of Helminthology , Volume 57 , Issue 3 , September 1983 , pp. 237 - 239
Copyright
Copyright © Cambridge University Press 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Banerjee, D., Om Prakash, & Deo, M. G. (1970 a) Studies on Ancylostoma caninum infection in mice following percutaneous and intraperitoneal routes of infection. Indian Journal of Medical Research, 58, 1313–1320.Google ScholarPubMed
Banerjee, D., Om Prakash, & Deo, M. G. (1970 b) Studies on the early stage of infection of Ancylostoma caninum in mice. Indian Journal of Medical Research, 58, 1321–1327.Google Scholar
Bhopale, M. K. & Johri, N. J. (1975) Experimental infection of Ancylostoma caninum in mice. II. Migration and distribution of larvae in tissues after oral infection. Journal of Helminthology, 49, 179–185.CrossRefGoogle ScholarPubMed
Fridovch, I. (1975) Superoxide dismutases. Annual Review of Biochemistry, 44, 147–159.Google Scholar
Fridovich, I. (1981) Superoxide radical and superoxide dismutases. In: Oxygen and living processes (Gilbert, D. L., Editor). Springer-Verlag, New York, Pp. 250–272.CrossRefGoogle Scholar
Huber, L. H. & Drath, D. B. (1981) Pulmonary oxygen toxicity. In: Oxygen And Living Processes (Gilbert, D. L., Editor), Springer-Verlag, New York, pp. 273–342.CrossRefGoogle Scholar
Keele, B. B. Jr, McCord, J. M. & Fridovich, I. (1970) Superoxide dismutase from E. coli B; a new manganese containing enzyme. Journal of Biological Chemistry, 245, 6176–6181.Google Scholar
Kimball, R. E., Reddy, K., Pierce, T. H., Schwartz, L. W., Mustafa, M. G. & Cross, C. E. (1976) Oxygen toxicity: Augmentation of antioxidant defence mechanisms in rat lungs. American Journal of Physiology, 230, 1425–1431.Google Scholar
Kono, M. & Sawada, T. (1961) Studies on hookworm immunity (Ancylostoma caninum). III. The migration of larvae in the body of mice infected with larvae. Kitakanto Igakce, 11, 432–438. [In Japanese With English Summary.]Google Scholar
Kulkarni, A. B., Deshpande, J. M., Sharma, K. D., Bapat, R. D., Kinare, S. G.Shirodkar, M. V., (1981 a) Hepatic superoxide dismutase activity in normal and hepatitis B virus infected langur monkeys. International Research Communication System Medical Science-Libary, Compendium, 9, 609.Google Scholar
Kulkarni, A. B., Ved, H. S., Ramakrishnan, P., Pradhan, V. R., Renapurkar, D. M. & Sharma, K. D. (1981 b) Studies on superoxide dismutase and catalase in different tissues of rat infected with plasmodium berghei. Bulletin of Haffkine Institute, 9, 29–33.Google Scholar
Leon, E. D. & Maldonado, J. F. (1971) Ancylostomiasis. In: Pathology of Protozoal and Helminthic Diseases (Marcial-Rojas, R. A.. Editor) Williams & Wilkins Co., Baltimore, Pp. 734–746.Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with Folin-Phenol reagent. Journal of Biological Chemistry, 193, 267–275.CrossRefGoogle ScholarPubMed
Marklund, S. & Marklund, G. (1974) Involvement of the superoxide anion radical in the oxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry, 47, 469–474.CrossRefGoogle Scholar
Mccord, J. M. & Fridovich, I. (1969) Superoxide dismutase—an enzyme function for erythro-cuprein (Hemocuprein). Journal of Biological Chemistry, 244, 6049–6055.Google Scholar
Nichols, R. L. (1956) The etiology of visceral larva migrans II. Comparative larval morphology of Ascaris lumbricoides, Neeator americans, Stronyvloides stercoralis and Ancxlostoma caninum. Journal of Parasilohgy. 42, 363–399.Google Scholar
Sen, H. G., Joshi, U. N. & Seth, D. (1965) Effect of cortisone upon ancylostoma caninum infection in albino mice. Transactions of the Royal Society of Tropical Medicine and Hygiene, 59, 684–689.Google Scholar
Sharma, O. P., Shukla, R. P.Singh, C. & Sen, A. B. (1979) Alterations in some biochemical parameters in mouse liver and spleen during infection with P. berghei. Indian Journal of Medical Research, 69, 944–948.Google Scholar
Shatzman, A. R. & Kosman, D. J. (1978) The utilization of copper and its role in the biosynthesis of copper-containing proteins in the fungus, Dactylium dendroides. Biochimica et Biophysica Acta, 544, 163–179.Google Scholar
Stevens, J. B. & Autor, A. P. (1977) Induction of sod by oxygen in neonatal rat lung. Journal of Biological Chemistry, 252, 3509–3514.Google Scholar
Weisiger, R. A. & Fridovich, I. (1973) Mitochondrial superoxide dismutase: site of synthesis and intramitochondrial localization. Journal of Biological Chemistry, 248, 4793–4796.CrossRefGoogle ScholarPubMed