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Protective efficacy of a filarial surface antigen in experimental filariasis

Published online by Cambridge University Press:  01 March 2009

N.N. Mandal ,
M.S. Bal ,
M.K. Das  and
M.K. Beuria
N.N. Mandal
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), Chandrasekharpur, Bhubaneswar751023, India
M.S. Bal
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), Chandrasekharpur, Bhubaneswar751023, India
M.K. Das
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), Chandrasekharpur, Bhubaneswar751023, India
M.K. Beuria*
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), Chandrasekharpur, Bhubaneswar751023, India
*
*Fax: +91 674 301351 E-mail: [email protected]
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Abstract

A water-insoluble, detergent-soluble, surface-associated glycoprotein, designated as Dssd1, was found to induce microfilaria clearance in Mastomys coucha implanted with Setaria digitata. Intraperitoneal implantation of adult female worms of S. digitata in M. coucha could induce microfilaraemia lasting about 165 days in circulation. Immunization of M. coucha with Dssd1 antigen either before or after implantation of worms resulted in a significant reduction in microfilaria density. Complete clearance of circulating microfilaria was achieved by immunization (before and after implantation) in animals by 95 and 105 days post-implantation, respectively, indicating the efficacy of Dssd1 antigen in the clearance of microfilaraemia in infected M. coucha.

Type
Research Papers
Information
Journal of Helminthology , Volume 83 , Issue 1 , March 2009 , pp. 47 - 50
Copyright
Copyright © Cambridge University Press 2009

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