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Pathophysiology of Mesocestoides corti infection in the mouse

Published online by Cambridge University Press:  18 November 2009

T. R. White ,
R. C. A. Thompson ,
W. J. Penhale ,
D. A. Pass  and
J. N. Mills
T. R. White
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150
R. C. A. Thompson
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150
W. J. Penhale
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150
D. A. Pass
Affiliation:
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150
J. N. Mills
Affiliation:
Applied Veterinary Medicine, School of Veterinary Studies, Murdoch University, Murdoch, Western Australia, 6150
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Abstract

Liver histology and serum enzyme and protein changes were studied in two strains of mice showing different initial susceptibilities to infection with Mesocestoides corti. The results show an increase in ALT and AST levels during the period of invasion and proliferation in the liver and a decrease in the levels of these two enzymes following encapsulation of the parasite in the liver and liver regeneration. A progressive loss of albumin was accompanied by increases in the levels of the beta- and gamma-globulins. These changes are discussed in the light of our knowledge of the effects of this parasite upon its host.

Type
Research Papers
Information
Journal of Helminthology , Volume 56 , Issue 2 , June 1982 , pp. 145 - 154
Copyright
Copyright © Cambridge University Press 1982

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References

REFERENCES

Bundesen, P. G. & Janssens, P. A. (1971a) Biochemical tracing of parasitic infection—I. Fasciola hepatica L. in mice—A qualitative study. International Journal of Parasitology, 1, 7–14.CrossRefGoogle Scholar
Bundesen, P. G., & Janssens, P. A. (1971b) Biochemical tracing of Parasitic Infections—II. Taenia pisiformis in rabbits—A quantitative study. International Journal for Parasitology, 1, 15–20.CrossRefGoogle ScholarPubMed
Campbell, W. C. & Barry, T. A. (1970) A biochemical method for the detection of anthelmintic activity against liver fluke (Fasciola hepatica). Journal of Parasitology, 56, 325–331.CrossRefGoogle ScholarPubMed
Dixon, J. B., Jenkins, P. & Allan, D. (1978) Blastic stimulation of unprimed mouse lymphocytes by living protoscolices of Echinococcus granulosus: a possible connection with transplant immunity. Journal of Parasitology, 64, 949–950.CrossRefGoogle ScholarPubMed
Henry, R. J., Chiamore, N., Golub, O. J. & Berkman, S. (1960) Revised spectrophotometric Methods for the determination of glutamic-oxalacetic transaminase, glutamic-pyruvie transaminase and lactic acid dehydrogenase, American Journal of Clinical Pathology, 34, 381–398.CrossRefGoogle ScholarPubMed
Lopez, J. S., Ramos, C., Willms, K., Sealey, M., Melendro, E. I. & Ortiz-Ortiz, L. (1980) B lymphocyte stimulation by parasitic organisms. In “Molecules, cells and parasites in Immunology” edited by Larralde, C., Willms, K., Ortiz-Ortiz, L. and Sela, M.Academic Press, London.Google Scholar
Mitchell, G. F. & Handman, E. (1977) Studies on immune responses to larval cestodes in mice. A simple mechanism of non-specific immunosuppression in Mesocestoides corti-infected mice. Australian Journal of Experimental Biology and Medical Science, 55, 615–622.CrossRefGoogle ScholarPubMed
Mitchell, G. F., Marchalonis, J. J., Smith, P. M., Nicholas, W. L. & Warner, N. L. (1977) Studies on immune responses to larval cestodes in mice. Immunoglobulins associated with the larvae of Mesocestoides corti. Australian Journal of Experimental Biology and Medical Science, 55, 187–211.CrossRefGoogle ScholarPubMed
Pollacco, C., Nicholas, W. L., Mitchell, G. F. & Stewart, A. C. (1978) T-cell dependent collagenous encapsulating response in the mouse liver to Mesocestoides corti (Cestoda). International Journal for Parasitology, 8, 457–462.CrossRefGoogle ScholarPubMed
Sadun, E. H., Williams, J. S., Meroney, F. C. & Hutt, G. (1965) Pathophysiology of Plasmodium berghei infection in mice. Experimental Parasitology, 17, 277–286.CrossRefGoogle Scholar
Specht, D. & Voge, M. (1965) Asexual multiplication of Mesocestoides tetrathyridia in laboratory animals. Journal of Parasitology, 51, 268–272.CrossRefGoogle ScholarPubMed
Specht, D. & Widmer, E. A. (1972) Response of mouse liver to infection with tetrathyridia of Mesocestoides (Cestoda). Journal of Parasitology, 58, 431–437.CrossRefGoogle ScholarPubMed
Todd, K. S. Jr., Simond, J. & Dipietro, J. A. (1978) Pathological changes in mice infected with tetrathyridia of Mesocestoides corti. Laboratory Animals, 12, 51–53.CrossRefGoogle ScholarPubMed
Weichselbaum, T. E. (1946) An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma. American Journal of Clinical Pathology, 16, 40–48.CrossRefGoogle Scholar
Wellde, B. T., Johnson, A. J., Williams, J. S. & Sadun, E. H. (1972) Experimental infection with Plasmodium fulciparum in Aotus monkeys. 1, Parasitologic, hematologic and serum biochemical determinations. American Journal of Tropical Medicine and Hygiene, 21, 260–287.CrossRefGoogle Scholar
White, T. R., Thompson, R. C. A., Pass, D. A., Penhale, W. J. & Stephanson, J. (1981) Pathological phenomena associated with Mesocestoides corti infection in mice. Journal of Helminthology, 55, 167–171. (Research Note.)CrossRefGoogle ScholarPubMed
White, T. R., Thompson, R. C. A. & Penhale, W. J. A comparative study of the susceptibility of inbred strains of mice to infection with Mesocestoides corti. International Journal for Parasitology. In Press.Google Scholar
Wilkinson, J. H., Boutwell, J. H. & Winsten, S. (1969) Evaluation of a new system for the kinetic measurement of serum alkaline phosphatase. Clinical Chemistry, 15, 487–495.CrossRefGoogle ScholarPubMed