Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-24T21:29:01.206Z Has data issue: false hasContentIssue false
  • English
  • Français

Parasite antigenaemia and IgG4 antibodies to a filarial protease in an endemic human population in India

Published online by Cambridge University Press:  12 April 2024

M.S. Bal ,
M.K. Beuria ,
N.N. Mandal  and
M.K. Das
M.S. Bal
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), PO Chandrasekharpur, Bhubaneswar 751023, Orissa, India
M.K. Beuria
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), PO Chandrasekharpur, Bhubaneswar 751023, Orissa, India
N.N. Mandal
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), PO Chandrasekharpur, Bhubaneswar 751023, Orissa, India
M.K. Das*
Affiliation:
Division of Immunology, Regional Medical Research Centre (Indian Council of Medical Research), PO Chandrasekharpur, Bhubaneswar 751023, Orissa, India
*
*Author for correspondence Fax: 91 0674 301351 E-mail: [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Levels of circulating filarial antigen (Og4C3) and IgG4 antibodies to a filarial protease were determined in subjects of Wuchereria bancrofti exposed sera from Orissa, India. In addition to all individuals with antigenaemia (microfilaraemia), IgG4 antibodies were also detected in some individuals without antigenaemia. A 2-year longitudinal follow-up indicated that IgG4 seropositivity in asymptomatic amicrofilaraemics could be a risk factor for acquiring infection (antigenaemia).

Type
Review Article
Information
Journal of Helminthology , Volume 77 , Issue 4 , December 2003 , pp. 287 - 290
Copyright
Copyright © Cambridge University Press 2003

References

Bal, M.S. & Das, M.K. (1999) Antigenicity of a filarial protease from Setaria digitata in Wuchereria bancrofti infection. Annals of Tropical Medicine and Parasitology 93, 279–288.CrossRefGoogle ScholarPubMed
Beuria, M.K., Bal, M.S., Mandal, N.N. & Das, M.K. (2001) A long-term follow-up of asymptomatic amicrofilaraemic individuals living in a filaria-endemic region of Orissa, India: infection and disease status. Transactions of the Royal Society of Tropical Medicine and Hygiene 95, 408–409.CrossRefGoogle Scholar
Chanteau, S., Glaziou, P., Plichart, C., Luquiaud, P., Moulia-Pelat, J.P., Niguyen, L. & Cartel, J.L. (1995) Wuchereria bancrofti filariasis in French Polynesia: age-specific patterns of microfilariae, circulating antigen and specific IgG and IgG4 responses according to transmission level. International Journal for Parasitology 25, 81–85.CrossRefGoogle Scholar
Chanteau, S., Moulia-Pelat, J.P., Glaziou, P., Niguyen, L., Luquiaud, P., Plichart, C., Martin, P.M.V. & Cartel, J.L. (1994) Og4C3 Circulating antigen: a marker of infection and adult worm burden in Wuchereria bancrofti filariasis. Journal of Infectious Diseases 170, 247–250.CrossRefGoogle ScholarPubMed
Das, M.K., Beuria, M.K. & Dash, A.P. (1992) Immunoglobulin E and G4 antibodies to infective larvae in a Wuchereria bancrofti endemic population. International Archives of Allergy and Immunology 99, 118–122.CrossRefGoogle Scholar
Dissanayake, S., Zheng, H., Dreyer, G., Xu, M., Watawana, L., Vince, A. & Piessens, W.F. (1994) Evaluation of recombinant filarial antigen for the diagnosis of lymphatic filariasis. American Journal of Tropical Medicine and Hygiene 50, 727–734.CrossRefGoogle ScholarPubMed
Egwang, T.G., Duong, T.H., Nguiri, C., Ngari, P., Everaere, S., Richard-Lenoble, D., Ggakima, A.A. & Kombila, M. (1994) Evaluation of Onchocerca volvulus specific IgG4 subclass serology as an index of onchocerciasis transmission potential of three Gabonese villages. Clinical and Experimental Immunology 98, 401–407.CrossRefGoogle ScholarPubMed
Hussain, R., Grogl, M. & Ottesen, E.A. (1987) IgG antibody subclasses in human filariasis. Differential subclass recognition of parasite antigen correlates with different clinical manifestation of infection. Journal of Immunology 139, 2794–2798.CrossRefGoogle ScholarPubMed
Langy, S., Plichart, C., Luquiaud, P., Williams, S.A. & Nicolas, L. (1998) The immunodominant B. malayi paramyosin as a marker of current infection with Wuchereria bancrofti adult worms. Infection and Immunity 66, 2854–2858.CrossRefGoogle Scholar
More, S.J. & Copeman, D.B. (1990) A highly specific and sensitive monoclonal antibody-based ELISA for the detection of circulating antigen in bancroftian filariasis. Tropical Medicine and Parasitology 14, 229–234.Google Scholar
Rahmah, N., Lim, B.H., Khairul, A.A., Shenoy, R.K., Kumaraswami, V., Lokman Hakim, A., Kanjanopas, K. & Ramachandran, C.P. (2001) A recombinant antigen-based IgG4 ELISA for the specific and sensitive detection of Brugia malayi infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 95, 280–284.CrossRefGoogle ScholarPubMed
Turner, P., Copeman, B., Gerisi, D. & Speare, R. (1993) A comparison of the Og4C3 antigen capture ELISA, the Knott test, an IgG4 assay and clinical signs in the diagnosis of bancroftian filariasis. Tropical Medicine and Parasitology 44, 45–48.Google ScholarPubMed
Weil, G.J., Ramzy, R.M., Chandrasekhar, R., Gad, A.M., Lowrie, R.C. Jr & Faris, R. (1996) Parasitic antigenemia without microfilaraemia in bancroftian filariasis. American Journal of Tropical Medicine and Hygiene 55, 333–337.CrossRefGoogle Scholar