Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-29T00:06:02.709Z Has data issue: false hasContentIssue false
  • English
  • Français

Nematospiroides dubius: stimulation of acquired immunity in inbred strains of mice

Published online by Cambridge University Press:  05 June 2009

Jerzy M. Behnke  and
D. Wakelin
Jerzy M. Behnke
Affiliation:
The Wellcome Laboratories for Experimental ParasitologyUniversity of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
D. Wakelin
Affiliation:
The Wellcome Laboratories for Experimental ParasitologyUniversity of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
Get access Rights & Permissions [Opens in a new window]

Abstract

The development of immunity to Nematospiroides dubius was studied in three strains of inbred mice (BALB/c, C3H and NIH). Although a primary infection in NIH mice persisted for two months without evidence of a reduction in worm numbers, female mice of this strain readily developed resistance to reinfection. The degree of resistance was enhanced when an immunizing infection of 600 larvae was administered as 6 separate doses of 100 larvae given between days 0 and 11, and the worms removed by anthelmintic treatment given on days 15, 21, 28 and 35. Immunity in mice immunized in this way was manifest both as a reduction in worm recoveries on days 9–14 after challenge and also as an expulsion of established worms from the intestine. BALB/c mice were initially less resistant, but expelled most of the worms which became established; C3H mice showed no evidence of expulsion. The finding that inbred NIH and BALB/c mice acquire resistance to N. dubius offers possibilities for the systematic analysis of lymphoid cell activity in initiating and expressing immunity to this parasite.

Type
Research Article
Information
Journal of Helminthology , Volume 51 , Issue 3 , September 1977 , pp. 167 - 175
Copyright
Copyright © Cambridge University Press 1977

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Baker, N. F. (1954) Trichostrongylidosis: The mouse as an experimental animal. Proceedings of the American Veterinary Medical Association, 91, 185–191.Google Scholar
Bartlett, A. and Ball, P. A. J. (1972) Nematospiroides dubius in the mouse as a possible model of endemic hookworm infection. Annals of Tropical Medicine and Parasitology, 66, 129–134.CrossRefGoogle Scholar
Bartlet, A. and Ball, P. A. J. (1974) The immune response of the mouse to larvae and adults of Nematospiroides dubius. International Journal for Parasitology, 4, 463–470.CrossRefGoogle Scholar
Bryant, V. (1973) The life cycle of Nematospiroides dubius, Baylis, 1926 (Nematoda: Heligmosomidae). Journal of Helminthology, 47, 263–268.CrossRefGoogle ScholarPubMed
Cypess, R. H. and Zidian, J. L. (1975) Heligmosomoides polygyrus (Nematospiroides dubius): The development of self-cure and/or protection in several strains of mice. Journal of Parasitology, 61, 819–824.Google Scholar
Durette-Desset, M. C., Kinsella, J. M. and Forrester, D. J. (1972) Arguments en faveur de la double origine des Nématodes du genre Heligmosomoides Hall, 1916. Annales de Parasitologie (Paris), 47, 365–382.Google Scholar
Jenkins, S. N. and Bhenke, J. M. (1977) Impairment of primary expulsion of Trichuris muris in mice concurrently infected with Nematospiroides dubius. Parasitology, 75, 71–78.CrossRefGoogle ScholarPubMed
Kelly, J. D., Love, R. J. and Dineen, J. K. (1974) Expulsion of Nippostrongylus brasiliensis from the intestine of rats: Attempts to initiate worm expulsion by cell transfer in an immunologically insert allogeneic environment. International Archives of Allergy and Applied Immunology, 46, 880–893.CrossRefGoogle Scholar
Larsh, J. E. and Race, G. J. (1975) Allergic inflammation as a hypothesis for the expulsion of worms from tissues: A review. Experimential Parasitology, 37, 251–266.CrossRefGoogle ScholarPubMed
Liu, S. K. (1966) Genetic influence on resistance of mice to Nematospiroides dubius. Experimental Parasitology, 18, 311–319.CrossRefGoogle Scholar
Love, R. J. (1975a) Nippostrongylus brasiliensis infection in rats. Both antibodies and sensitized cells are necessary for the immunological control of developing larvae. International Archives of Allergy and Applied Immunology, 48, 211–219.Google Scholar
Love, R. J. (1975b) Nippostrongylus brasiliensis infections in mice: the immunological basis of worm expulsion. Parasitology, 70, 11–18.Google Scholar
Ogilvie, B. M. and Love, R. J. (1974) Co-operation between antibodies and cells in immunity to a nematode parasite. Transplantation Reviews, 19, 147–168.Google Scholar
Ogilvie, B. M. and Jones, V. E. (1968) Passive protection with cells or antiserum against Nippostrongylus brasiliensis in the rat. Parasitology, 58, 939–949.Google Scholar
Panter, H. C. (1969a) Host-parasite relationship of Nematospiroides dubius in the mouse. Journal of Parasitology, 55, 33–37.CrossRefGoogle Scholar
Panter, H. C. (1969b) The mechanism of immunity of mice to Nematospiroides dubius. Journal of Parasitology, 55, 38–43.Google Scholar
Wakelin, D. (1975) Immune expulsion of Trichuris muris from mice during a primary infection: analysis of the components involved. Parasitology, 70, 397–405.Google Scholar
Wakelin, D. and Lloyd, M. (1976) Accelerated expulsion of adult Trichinella spiralis in mice given lymphoid cells and serum from infected donors. Parasitology, 72, 307–315.CrossRefGoogle ScholarPubMed
Van Zandt, P. D. (1961) Studies on the immunity relationship in white mice given infections with Nematospiroides dubius. Journal of the Elisha Mitchell Scientific Society, 77, 300–309.Google Scholar