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The minimum effective dose of praziquantel in treatment of Hymenolepis diminuta in rats

Published online by Cambridge University Press:  05 June 2009

P.C. Fan  and
A. Ito
P.C. Fan
Affiliation:
Department of Parasitology, National Yangming Medical College, Taipei, Taiwan, Republic of China
A. Ito
Affiliation:
Department of Parasitology, Gifu University School of Medicine, Gifu City, Japan
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Abstract

To determine the minimum effective dose of praziquantel against Hymenolepis diminuta in rats, 5.0 mg/kg, 2.5 mg/kg, 1.0 mg/kg, 0.5 mg/kg, 0.1 mg/kg, or 0.05 mg/kg praziquantel were given to each of five experimentally infected rats in six groups. Faecal samples from each rat were examined for worms on day 10. Based on the results of faecal examination and autopsy, the minimum effective dose of praziquantel against Hymenolepis diminuta in rats was determined to be 0.5 mg/kg.

Type
Research Note
Information
Journal of Helminthology , Volume 69 , Issue 1 , March 1995 , pp. 91 - 92
Copyright
Copyright © Cambridge University Press 1995

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References

Becker, B., Mehlhorn, H., Andrews, P. & Thomas, H. (1990) Scanning and transmission electron microscope studies on the efficacy of praziquantel on H. nana (Cestoda) in vitro. Zeitschrift für Parasitenkunde 61, 121–133.CrossRefGoogle Scholar
Dixon, B.R. & Arai, H.P. (1991) Anthelmintic-induced destrobilation and its influence on calculated drug efficacy in Hymenolepis diminuta infections in rats. Journal of Parasitology 77, 769–774.CrossRefGoogle ScholarPubMed
Fan, P.C. & Chang, K.C. (1990) Parasitic infections among rodents and house shrews in Northern Taiwan. Chinese Journal of Parasitology 3, 79–85.Google Scholar
Fan, P.C., Lin, C.Y. (1991) Intestinal parasitic infections in laboratory animals. Chinese Journal of Parasitology 4, 37–44.Google Scholar
Fan, P.C., Chung, W.C. & Lin, C.Y. (1992) Review: Therapeutic efficacy of mebendazole, praziquantel, albendazole and niclosamide for the treatment of Taiwan Taenia infection. Proceedings of 2nd Asian-Pacific Congress for Parasitic Zoonoses, Taipei 2, 40–52.Google Scholar
Ito, A. & Onitake, K. (1987) Hymenolepis diminuta and H. nana: Cross immunity against the lumen phase in BALB/c mice. Experimental Parasitology 64, 48–56.CrossRefGoogle Scholar
Lin, C.Y. & Fan, P.C. (1991) Evaluation of efficacy of praziquantel against cysticercosis of Taenia saginata-like tapeworm (Taiwan strain) in pigs. Annals of Tropical Medicine and Parasitology 85, 439–442.CrossRefGoogle ScholarPubMed
Stroll, N.R. & Hausheer, W.C. (1926) Concerning two options in dilution egg counting: small drop and displacement. American Journal of Hygiene 6, 134–145.Google Scholar
Thomas, H. & Andrews, P. (1977) Praziquantel – a new cestocide. Pesticide Science 8, 556–560.CrossRefGoogle Scholar
Thomas, H. & Gönnert, R. (1977) The efficacy of praziquantel against cestodes in animals. Zeitschrift für Parasitenkunde 52, 117–127.CrossRefGoogle ScholarPubMed