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Induction of host resistance to Brugia pahangi in jirds (Meriones unguiculatus) protected by chemoprophylaxis

Published online by Cambridge University Press:  05 June 2009

W. Chusattayanond  and
D. A. Denham
W. Chusattayanond
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WCIE 7HT
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WCIE 7HT
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Abstract

Jirds were given a chcmoprophylactic inoculation of flubendazole (FMBZ) and then five injections of infective larvae of Brugia pahangi whilst still protected by the FMDZ. When the drug was thought to be noneffective the jirds (and controls) were given a challenge infection of B. pahangi larvae. By comparison with control jirds the trcatcd-infectcd-challcnged jirds had 40% fewer adult worms. The control treated-challenged jirds contained mostly sterile female worms showing that they were still partially protected by FMBZ but worms numbers were not significantly reduced as compared with untreated controls.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 3 , September 1984 , pp. 245 - 249
Copyright
Copyright © Cambridge University Press 1984

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References

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