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In vitro tapeworm extract-induced proliferative responses of gut-associated lymphoid cells from Hymenolepis diminuta infected mice

Published online by Cambridge University Press:  05 June 2009

Dale D. Isaak
Dale D. Isaak
Affiliation:
Department of Microbiology and Immunology, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA.
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Abstract

The development of lymphoid cells reactive to tapeworm-associated antigens during the course of Hymenolepis diminuta rejection from mice was studied using an in vitro tapeworm extract (TWE)-induced cell proliferation culture system. Mice infected with three cysticercoids on day 0 developed three adult worms by day 7 but worms were rejected by day 21 post-infection. Concomitant with worm rejection was the development of TWE-sensitized lymphoid cells which responded by proliferation when stimulated in vitro with TWE. Sensitized cells were detected in gut-associated mesenteric lymph nodes but were not detected in spleen, axillary lymph nodes, or peyer's patches of infected mice, or in lymphoid organs of non-infected mice. These studies suggest that rejection of H. diminuta from mice is associated with the activities of gut-associated, tapeworm antigen-sensitized immune cells localized in the mesenteric lymph nodes.

Type
Research Papers
Information
Journal of Helminthology , Volume 57 , Issue 1 , March 1983 , pp. 43 - 50
Copyright
Copyright © Cambridge University Press 1983

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