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Immunodepression in hamsters experimentally infected with Opisthorchis viverrini

Published online by Cambridge University Press:  05 June 2009

S. Wongratanacheewin ,
W. Rattanasiriwilai ,
R. Priwan  and
S. Sirisinha
S. Wongratanacheewin
Affiliation:
Department of Microbiology, Faculty of Science, Mahidol University, Rana VI Road, Bangkok 10400, Thailand
W. Rattanasiriwilai
Affiliation:
Department of Microbiology, Faculty of Science, Mahidol University, Rana VI Road, Bangkok 10400, Thailand
R. Priwan
Affiliation:
Department of Microbiology, Faculty of Science, Mahidol University, Rana VI Road, Bangkok 10400, Thailand
S. Sirisinha*
Affiliation:
Department of Microbiology, Faculty of Science, Mahidol University, Rana VI Road, Bangkok 10400, Thailand
*
*For all correspondence
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Abstract

Hamsters experimentally infected with Opisthorchis viverrini had significant depression of the antibody response to sheep red blood cells. The depression was more severe with prolonged infections. Lymphoproliferative response to phytohaemagglutinin stimulation was also depressed when compared with uninfected controls. The immunodepression in these animals was abolished by anthelmintic treatment, suggesting that the immunodepressive effect is reversible and is associated with active infection.

Keywords

Opisthorchis viverrinihamsterimmunodepression
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 2 , June 1987 , pp. 151 - 156
Copyright
Copyright © Cambridge University Press 1987

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References

REFERENCES

Alekseeva, M. I., Boglazova, E. K., Lebedev, K. A. & Lukashenko, T. N. (1980). Suppression of macrophages in trematode infections. In: 9 Konferentsiya Ukrainskogo Parazitologicheskogo Obshchestva Tezisy dokladov Chast'l. pp. 21–22, Kiev, U.S.S.R.Google Scholar
Bauminger, S. & Peleg, S. (1978). Changes in immunological activity of rat lymphoid organ during pregnancy. Clinical and Experimental Immunology, 32, 179–185.Google ScholarPubMed
Boyum, A. (1968). Isolation of mononuclear cells and granulocytes from human blood. Scandinavian Journal of Laboratory and Clinical Investigation, 21, (Suppl 97), 77–89.Google Scholar
Cunninghama, J. & Szenberg, A. (1968). Further improvements in the plaque technique for detecting single antibody-forning cells. Immunology, 14, 599–600.Google Scholar
Fox, R. H., Dudley, F. J., Samuels, M., Milligan, J. & Sherlock, S. (1973). Lymphocyte transformation in response to phytohaemagglutinin in primary biliary cirrhosis. The search for a plasma inhibiting factor. Gut, 14, 89–93.CrossRefGoogle Scholar
Goose, J. (1978). Possible role of excretory/secretory products in evasion of host defenses by Fasciola hepatica. Nature, 275, 216–217.CrossRefGoogle ScholarPubMed
Hsu, C. C. S. & Leevy, C. M. (1971). Inhibition of PHA-stimulated lymphocyte transformation by plasma from patients with advanced alcoholic cirrhosis. Clinical and Experimental Immunology, 8, 749–760.Google ScholarPubMed
Nakao, M., Mizoguchi, Y., Monna, T., Yamamoto, S. & Morisawa, S. (1978). Studies on an inhibitory factor to phytohemagglutinin-induced lymphocyte transformation found in the serum of patients with various liver diseases. Acta Hepato-Gastroenterologica, 25, 335–343.Google Scholar
O'keefe, S. J., El-zayadi, A. R., Carraher, T. E., Davis, M. & Williams, R. (1980). Malnutrition and immunoincompetence in patients with liver disease. Lancet, 2, 615–617.CrossRefGoogle ScholarPubMed
Sirisinha, S., Tuti, S., Tawatsin, A. & Rattanasiriwilai, W. (1982). Lack of evidence for protective immunity in hamsters infected with Opisthorchis viverrini. In: Immunology of Tropical Parasitic Infections in Asia and Pacific Region, (editors, Mak, J. W. & Yong, H. S.). pp. 91–100. Kuala Lumpur.Google Scholar
Sirisinha, S., Tuti, S., Vichasri, S. & Tawatsin, A. (1983). Humoral immune responses in hamsters infected with Opisthorchis viverrini. Southeast Asian Journal of Tropical Medicine and Public Health, 14, 243–251.Google ScholarPubMed
Smithers, S. R. & Doenhoff, M. J. (1982). Schistosomiasis. In: Immunology of Parasitic Infection, (editors, Cohen, S. & Warren, K. S.). 2nd edition, pp. 527–607. Blackwell Scientific Publications: London.Google Scholar
Sun, T. & Gibson, J. B. (1969). Antigens of Clonorchis sinensis in experimental and human infections. American Journal of Tropical Medicine and Hygiene, 18, 241–252.CrossRefGoogle ScholarPubMed
Tawatsin, A., Sirisinha, S., Vajrasthira, S., Bunnag, D. & Harinasuta, T. (1984). Evaluation of selected anthelmintic compounds for activity against Opisthorchis viverrini. Tropenmedizin und Parasitologie, 35, 85–90.Google ScholarPubMed
Terry, R. & Hudson, K. (1982). Immunodepression in parasitic infections. Fortshritte der Zoologie, 27, 125–139.Google Scholar
Zimmerman, G. L., Isaacson kerkvliet, N., Brauner, J. A. & Cerro, J. E. (1983). Modulation of host immune responses by Fasciola hepatica: responses of peripheral lymphocytes to mitogens during liver fluke infections of sheep. Journal of Parasitology, 69, 473–477.CrossRefGoogle ScholarPubMed