Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-23T05:19:43.389Z Has data issue: false hasContentIssue false
  • English
  • Français

The immune response of male DSN hamsters to a primary infection with Ancylostoma ceylanicum

Published online by Cambridge University Press:  05 June 2009

Paul Garside ,
Jerzy M. Behnke  and
Richard A. Rose
Paul Garside
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, Nottingham NG7 2RD, UK
Jerzy M. Behnke*
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, Nottingham NG7 2RD, UK
Richard A. Rose
Affiliation:
MRC Experimental Parasitology Research Group, Department of Zoology, University of Nottingham, Nottingham NG7 2RD, UK
*
* Author to whom all correspondence should be addressed.
Get access Rights & Permissions [Opens in a new window]

Abstract

The immune response of hamsters to a chronic hookworm infection has been investigated. Ancylostoma ceylanicum caused long term infections in hamsters which were associated with prominent changes in secondary lymphoid organs. The mesenteric lymph nodes and spleens increased rapidly in size stabilizing at approximately 3–4 times the weight in control animals by weeks 3–7. Cells from both the mesenteric lymph node and spleen, after an initial period of increased blast cell activity, became less reactive in the latter stages of infection. Serum antibody responses were marked, commencing in weeks 3–4 and increasing in intensity throughout the 10 week period of measurement. The results are discussed in relation to their contribution to the understanding of human hookworm infection.

Keywords

Ancylostoma ceylanicumhamsterimmune responseprimary infection
Type
Research Article
Information
Journal of Helminthology , Volume 63 , Issue 3 , September 1989 , pp. 251 - 260
Copyright
Copyright © Cambridge University Press 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Anten, J. F. G. & Zuidema, P. J. (1964) Hookworm infection in Dutch servicemen returning from West New Guinea. Tropical and Geographical Medicine, 16, 216–224.Google ScholarPubMed
Behnke, J. M. (1987) Do hookworms elicit protective immunity in Man? Parasitology Today, 3, 200–205.CrossRefGoogle ScholarPubMed
Carr, A. & Pritchard, D. I. (1986) Identification of hookworm (Necator americanus) antigens and their translation in vitro. Molecular and Biochemical Parasitology, 19, 251–258.CrossRefGoogle ScholarPubMed
Carroll, S. M. & Grove, D. I. (1984) Parasitological, hematologic, and immunologic responses in acute and chronic infections of dogs with Ancylostoma ceylanicum: a model of human hookworm infection. The Journal of Infectious Diseases, 150, 284–293.CrossRefGoogle Scholar
Carroll, S. M. & Grove, D. I. (1985) Resistance of dogs to reinfection with Ancylostoma ceylanicum following anthelmintic therapy. Transactions of the Royal Society of Tropical Medicine and Hygiene, 79, 519–523.CrossRefGoogle ScholarPubMed
Carroll, S. M. & Grove, D. I. (1986) Experimental infection of humans with Ancylostoma ceylanicum: clinical, parasitological, haematological and immunological findings. Tropical and Geographical Medicine, 38, 38–45.Google ScholarPubMed
Garside, P. & Behnke, J. M. (1989) Primary infection of hamsters with Ancylostoma ceylanicum. Parasitology, 98, 283–289.CrossRefGoogle ScholarPubMed
Kamath, V. R., Bhopale, M. K. & Bhide, M. B. (1985) Immunological evidence of chemotherapeutic action of mebendazole against Ancylostoma ceylanicum (Looss, 1911) in hamsters (Mesocricetus auratus). Journal of Helminthology, 59, 195–199.CrossRefGoogle ScholarPubMed
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.CrossRefGoogle ScholarPubMed
Palmer, E. D. (1955) Course of egg output over a 15 year period in a case of experimentally induced necatoriasis americanus, in the absence of hyperinfection. American Journal of Tropical Medicine and Hygiene, 4, 756–757.CrossRefGoogle Scholar
Ray, D. K., Bhopale, K. K. & Shrivastava, V. B. (1972) Complete development of Ancylostoma ceylanicum in golden hamsters, Mesocricetus auratus. Experientia, 28, 359–361.CrossRefGoogle ScholarPubMed
Roche, M. & Layrisse, M. (1966) The nature and cause of “Hookworm anemia”. American Journal of Tropical Medicine and Hygiene, 15, 1030–1100.CrossRefGoogle ScholarPubMed
Sen, H. G. & Seth, D. (1967) Complete development of the human hookworm, Necator americanus, in golden hamsters, Mesocricetus auratus. Nature, 214, 609–610.CrossRefGoogle Scholar
Visen, P. K. S., Katiyar, J. C. & Sen, A. B. (1984) Studies on infectivity, longevity and fecundity of Ancylostoma ceylanicum in golden hamsters. Journal of Helminthology, 58, 159–163.CrossRefGoogle ScholarPubMed
Wakelin, D. & Donachie, A. M. (1983) Genetic control of eosinophilia. Mouse strain variation in response to antigens of parasite origin. Clinical and Experimental Immunology, 51,239–246.Google ScholarPubMed
Wakelin, D., Mitchell, L. A., Donachie, A. M. & Grencis, R. K. (1985) Genetic control of immunity to Trichinella spiralis in mice. Response of rapid- and slow-responder strains to immunisation with parasite antigens. Parasite Immunology, 8, 159–170.CrossRefGoogle Scholar
White, C. J., Maxwell, C. J. & Gallin, J. I. (1986) Changes in the structural and functional properties of human eosinophils during experimental hookworm infection. The Journal of Infectious Diseases, 134, 778–783.CrossRefGoogle Scholar