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Host–parasite interactions in rodent nematode infections

Published online by Cambridge University Press:  12 April 2024

Y.R. Mahida
Y.R. Mahida*
Affiliation:
Division of Gastroenterology, University Hospital, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
*
* Fax: +44 (0) 115 849 3212, E-mail: [email protected].
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Abstract

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In rodents, Trichinella spiralis and Nippostrongylus brasiliensis infect the small intestine and Trichuris muris resides in the colon. The intestinal host response in these animals is characterized by changes in mucosal architecture and inflammation and is associated with worm expulsion. The requirement of T cell-mediated host response in worm expulsion has been demonstrated over many years. Subsequent studies have shown that Th2-type, but not Th1-type, responses mediate resistance to the nematodes. Investigations using neutralizing antibodies and genetically manipulated mice have characterized the contribution of individual Th2-type cytokines in not only worm expulsion, but also specific cellular changes that occur in the mucosa, such as alterations in epithelial phenotype and smooth muscle. There is also increasing appreciation of the contribution of non-bone marrow-derived cells in innate and adaptive host responses in these models.

Type
Research Article
Information
Journal of Helminthology , Volume 77 , Issue 2 , June 2003 , pp. 125 - 131
Copyright
Copyright © Cambridge University Press 2003

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