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Haematological changes in the laboratory rat Rattus norvegicus infected with Echinostoma caproni (Trematoda: Echinostomatidae)

Published online by Cambridge University Press:  03 June 2014

C. Muñoz-Antoli ,
A. Cortés ,
D. Torres ,
J.G. Esteban  and
R. Toledo
C. Muñoz-Antoli*
Affiliation:
Departamento Parasitología, Facultad Farmacia, Universidad Valencia, Avda. Vicent Andrés Estelles s/n, 46100-Burjassot-Valencia, España
A. Cortés
Affiliation:
Departamento Parasitología, Facultad Farmacia, Universidad Valencia, Avda. Vicent Andrés Estelles s/n, 46100-Burjassot-Valencia, España
D. Torres
Affiliation:
Departamento Parasitología, Facultad Farmacia, Universidad Valencia, Avda. Vicent Andrés Estelles s/n, 46100-Burjassot-Valencia, España
J.G. Esteban
Affiliation:
Departamento Parasitología, Facultad Farmacia, Universidad Valencia, Avda. Vicent Andrés Estelles s/n, 46100-Burjassot-Valencia, España
R. Toledo
Affiliation:
Departamento Parasitología, Facultad Farmacia, Universidad Valencia, Avda. Vicent Andrés Estelles s/n, 46100-Burjassot-Valencia, España
*
*E-mail: [email protected]
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Abstract

To study possible indirect effects of the infection with intestinal helminths, 12 Rattus norvegicus (Wistar) were each experimentally exposed to 100 metacercariae of Echinostoma caproni, and blood samples were taken weekly up to 4 weeks post-exposure for comparison with control rats. Values of haematocrit (HCT), red blood cells (RBC), platelets (PLT), white blood cells (WBC), haemoglobin (HGB) and haematimatrix indices, and mean corpuscular haemoglobin concentrations (MCHC) were determined. In addition, leucocyte counts, including lymphocytes, neutrophils, monocytes, eosinophils and basophils were analysed. These parameters, including the leucocyte counts, showed no significant differences, except for MCHC at 4 weeks post-exposure. The present results indicate that in rats infected with E. caproni, although eosinophilia did not significantly increase, a significant reduction in MCHC was associated with an increase in the number of RBC.

Type
Short Communications
Information
Journal of Helminthology , Volume 89 , Issue 5 , September 2015 , pp. 636 - 640
Copyright
Copyright © Cambridge University Press 2014 

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