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Fasciola antigens as vaccines against fascioliasis and schistosomiasis

Published online by Cambridge University Press:  12 April 2024

G.V. Hillyer*
Affiliation:
Department of Pathology and Laboratory Medicine, University of Puerto Rico School of Medicine, PO Box 365067, San Juan, PR 00936-5067, Puerto Rico
*
*Author for correspondence Fax: (787) 751 9210 E-mail: [email protected]
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Abstract

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Fascioliasis is an important trematode infection of herbivores worldwide with increasing evidence of prevalence as a disease of humans. Vaccination studies with purified native and recombinant Fasciola antigens suggest that this approach to diminished morbidity and mortality and reduced transmission is a realistic goal. Among the major potential vaccine candidates are fatty acid binding protein (FABP), cysteine (cathepsin) proteases, haemoglobulin, leucine aminopeptidase, and a saposin-like protein. In the case of Fasciola hepatica FABP, cross-reaction and cross-protection against Schistosoma mansoni is an important feature. In addition to protective effects with significant worm burden reductions, some vaccine candidates also have anti-fecundity (smaller flukes), anti-pathology (less liver lesions), and anti-embryonation effects. Optimism is tempered by the fact that fascioliasis in humans is an orphan disease and in need of governmental and foundation support.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2005

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