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Expression of tenascin in bile duct cancer of hamster liver by combined treatment of dimethylnitrosamine with Opisthorchis viverrini infections

Published online by Cambridge University Press:  12 April 2024

P. Sithithaworn ,
K. Ando ,
W. Limviroj ,
S. Tesana ,
C. Pairojkul ,
W. Yutanawiboonchai ,
Y. Chinzei ,
T. Yoshida  and
T. Sakakura
P. Sithithaworn*
Affiliation:
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
K. Ando*
Affiliation:
Department of Medical Zoology, School of Medicine, Mie University, Tsu 514-0001, Japan.
W. Limviroj
Affiliation:
Department of Medical Zoology, School of Medicine, Mie University, Tsu 514-0001, Japan.
S. Tesana
Affiliation:
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
C. Pairojkul
Affiliation:
Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
W. Yutanawiboonchai
Affiliation:
Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Y. Chinzei
Affiliation:
Department of Medical Zoology, School of Medicine, Mie University, Tsu 514-0001, Japan.
T. Yoshida
Affiliation:
Department of Pathology, School of Medicine, Mie University, Tsu 514-0001, Japan.
T. Sakakura
Affiliation:
Department of Pathology, School of Medicine, Mie University, Tsu 514-0001, Japan.
*
*Author for correspondence Fax: + 81 59 231 5215 E-mail: [email protected]
*Author for correspondence Fax: + 81 59 231 5215 E-mail: [email protected]
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Abstract

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Tenascin is an extracellular matrix glycoprotein known to be an essential factor for the modulation of reciprocal interactions between the epithelium and mesenchyme during embryogenesis and tumourigenesis. The interactions between the expression of tenascin in the liver of Syrian golden hamster and the development of bile duct cancer in an Opisthorchis viverrini-associated cholangiocarcinoma model were investigated. The tenascin was expressed in connective tissues surrounding the dilated ducts, ductal rims and the stroma of cancers, and strongly in the stroma flame of necrotic cancer nodules. The mRNA signal for tenascin was also recognized in the stroma cells. The potential roles of tenascin as prognostic tumour markers are discussed.

Type
Review Article
Information
Journal of Helminthology , Volume 76 , Issue 3 , September 2002 , pp. 261 - 268
Copyright
Copyright © Cambridge University Press 2002

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