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The expression of sICAM-1 influenced by Clonorchis sinensis co-infection in CHB patients

Published online by Cambridge University Press:  28 October 2024

J. Qiu ,
M. Shang ,
W. Li ,
H. Zhang ,
Y. Liao Open the ORCID record for Y. Liao [Opens in a new window]  and
H. Dong Open the ORCID record for H. Dong [Opens in a new window]
J. Qiu
Affiliation:
Department of Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People’s Republic of China
M. Shang
Affiliation:
Department of Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People’s Republic of China
W. Li
Affiliation:
Department of Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People’s Republic of China
H. Zhang
Affiliation:
Department of Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People’s Republic of China
Y. Liao*
Affiliation:
Department of Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People’s Republic of China
H. Dong*
Affiliation:
Department of Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People’s Republic of China
*
Corresponding authors: H. Dong and Y. Liao; Emails: [email protected]; [email protected]
Corresponding authors: H. Dong and Y. Liao; Emails: [email protected]; [email protected]
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Abstract

Soluble Intercellular Adhesion Molecule-1 (sICAM-1) has emerged as an inflammatory biomarker of many essential functions. We investigated the level of sICAM-1 influenced by Clonorchis sinensis (C. sinensis) co-infection in chronic hepatitis B (CHB) patients to explore the degree of liver tissue inflammation and liver function damage after co-infection. The study included data from patients with C. sinensis mono-infection (n=27), hepatitis B virus (HBV) mono-infection (n=32), C. sinensis and HBV co-infection (n=24), post-hepatitis B liver cirrhosis (n=18), post-hepatitis B liver cirrhosis co-infected with C. sinensis (n=16), and healthy controls (n=39). The level of sICAM-1 was measured with specific enzyme-linked immunosorbent assay method. Compared to the healthy control group, all the experimental groups had significantly higher serum sICAM-1 levels. The levels of sICAM-1 in co-infected groups were significantly higher compared to the mono-infection groups and were positively correlated with the levels of glutamate aminotransferase (ALT) and aspartate aminotransferase (AST). Our research findings confirmed that co-infection could exacerbate liver tissue inflammation and liver function damage in patients, could raise the sICAM-1 level, and may lead to the chronicity of HBV infection. These results provide clues for pathological mechanism study and formulating treatment plans.

Keywords

sICAM-1Clonorchis sinensishepatitis B virusco-infection
Type
Research Paper
Information
Journal of Helminthology , Volume 98 , 2024 , e54
Copyright
© The Author(s), 2024. Published by Cambridge University Press

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