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Experimental murine model of neurocysticercosis: first report of cerebellum as a location for Mesocestoides corti tetrathyridia

Published online by Cambridge University Press:  01 August 2018

J. Fabbri  and
M.C. Elissondo Open the ORCID record for M.C. Elissondo [Opens in a new window]
J. Fabbri
Affiliation:
Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3250, 7600, Mar del Plata, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
M.C. Elissondo*
Affiliation:
Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3250, 7600, Mar del Plata, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
*
Author for correspondence: M.C. Elissondo, Fax.: +54 223 475 3150 E-mail: [email protected]
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Abstract

Neurocysticercosis is a parasitic disease caused by encysted larvae of Taenia solium in the human central nervous system. Cysts mainly affect the cerebral hemispheres, although they can also be found in ventricles, basal cisterns, and subarachnoid spaces, and rarely in the cerebellum. Given the impossibility of studying the disease in human patients, Cardona et al. (1999) developed a mouse model of neurocysticercosis, using Mesocestoides corti, a closely related cestode. This allows us to study the parasite–host relationship and the mechanisms involved in the disease, in order to improve the therapy. In this murine model of neurocysticercosis, the location of tetrathyridia in parenchyma, ventricles and meninges has already been reported. The aim of this work is to report the cerebellum as a new location for M. corti tetrathyridia in the murine model of neurocysticercosis. A murine model that reproduces the human pathology is essential to evaluate the symptomatology and response to drug treatment in experimentally infected mice.

Keywords

CerebellumMesocestoides cortineurocysticercosisTaenia solium
Type
Short Communication
Information
Journal of Helminthology , Volume 93 , Issue 5 , September 2019 , pp. 640 - 642
Copyright
Copyright © Cambridge University Press 2018 

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