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Evidence for increased susceptibility of Brugia pahangi-infected jirds (Meriones unguiculatus) to subsequent homologous infections

Published online by Cambridge University Press:  05 June 2009

Thomas R. Klei ,
John W. McCall  and
John B. Malone
Thomas R. Klei
Affiliation:
Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA
John W. McCall
Affiliation:
Department of Parasitology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
John B. Malone
Affiliation:
Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA
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Abstract

The effect of existing Brugia pahangi infections on the establishment of a subsequent population was studied using jirds which had pre-challenge infections of 4 and 8 months duration. Necropsies were performed 28 days post-challenge inoculation in order to separate challenge and initial worm populations. The results indicate that existing infections of 4 or 8 months duration increase the susceptibility to subsequent homologous infections. The location of challenge population worms in tissue sites examined did not differ significantly between previously infected and uninfected groups. Previous infections did not affect the early growth of challenge population worms as indicated by their length.

Type
Research Papers
Information
Journal of Helminthology , Volume 54 , Issue 3 , September 1980 , pp. 161 - 166
Copyright
Copyright © Cambridge University Press 1980

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References

REFERENCES

Ah, H. S., Peckham, J. C., Mitchell, F. E., and Thompson, P. E. (1972) Studies on Dirofilaria immitis infections in dogs relative to immunizations and antigen-antibody interactions. In Canine Heartworm Disease: The Current Knowledge (Ed Bradley, R. E.), pp. 55–67. Institute of Food and Agricultural Sciences, University of Florida, Gainesville.Google Scholar
Ah, H. S. and Thompson, P. E. (1973) Brugia pahangi: Infections and their effect on the lymphatic system of Mongolian jirds (Meriones unguiculatus). Experimental Parasitology, 34, 393–411.CrossRefGoogle ScholarPubMed
Ah, H. S., Klei, T. R., McCall, J. W. and Thompson, P. E. (1974) Brugia pahangi: infections in Mongolian jirds and dogs following the ocular inoculation of infective larvae. Journal of Parasitology, 60, 643–648.CrossRefGoogle ScholarPubMed
Ash, L. R and Riley, J. M. (1970) Development of Brugia pahangi in the jird (Meriones unguiculatus) with notes on infections in other rodents. Journal of Parasitology, 56, 962–968.CrossRefGoogle ScholarPubMed
Dalesandro, D. and Klei, T. R. (1976) Evidence for immunodepression of Syrian hamsters and Mongolian jirds by Dipetalonema vitae infections. Transactions of the Royal Society of Tropical Medicine and Hygiene, 70, 534–535.CrossRefGoogle Scholar
Denham, D. A. and McGreevy, P. B. (1978) Brugian Filariasis: Epidemiological and Experimental Studies. Advances in Parasitology, 16, 243–309.Google Scholar
Denham, D. A., Ponnudurai, T., Nelson, G. S., Rogers, R. and Guy, F. (1972) Studies with Brugia pahangi—II. The effect of repeated infection on parasite levels in cats. International Journal for Parasitology, 2, 401–407.CrossRefGoogle ScholarPubMed
Grove, D. I. and Forbes, I. J. (1979) Immunosuppression in bancroftian filariasis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 73, 23–26.CrossRefGoogle ScholarPubMed
Haque, A., Chassoux, D., Ogilvie, B. M., and Capron, A. (1978) Dipetalonema vitae infection in hamsters: enhancement and suppression of microfiliaraemia. Parasitology, 76, 77–84.CrossRefGoogle Scholar
Kowalski, J. C. and Ash, L. R. (1975) Repeated infections of Brugia pahangi in the jird, Meriones unguiculatus. Southeast Asian Journal of Tropical Medicine and Public Health, 6, 195–198.Google ScholarPubMed
Macdonald, E. M. and Scott, J. A. (1958). The persistence of acquired immunity to the filarial worm of the cotton rat. American Journal of Tropical Medicine and Hygiene, 7, 419–422.CrossRefGoogle Scholar
Malone, J. B. (1974) Brugia pahangi model infections: Susceptibility of Mongolian jirds after X-irradiation or prior infection and pathological studies in golden hamsters. Doctoral Dissertation, University of Georgia, Athens, Georgia, U.S.A.Google Scholar
Neilson, J. T. M. (1976) A comparison of the acquired resistance to Dipetalonema viteae stimulated in hamsters by trickle versus tertiary infections. Tropenmedizin und Parasitologie, 27, 233–237.Google ScholarPubMed
Neilson, J. T. M. and Forrester, D. J. (1975) Dipetalonema viteae: Primary, secondary and tertiary infections in hamsters. Experimental Parasitology, 37, 367–372.CrossRefGoogle ScholarPubMed
Ottesen, E. A., Weller, P. F., and Heck, L. (1977) Specific cellular immune unresponsiveness in human filariasis. Immunology, 33, 413–421.Google ScholarPubMed
Otto, G. F. (1970) Insect-borne nematodes. In: Immunity to Parasitic Animals (Jackson, G. J.), pp. 963–980. Appleton-Century-Crofts: New York.Google Scholar
Portaro, J. K., Britton, S. and Ash, L. R. (1976) Brugia pahangi: Depressed mitogen reactivity in filarial infections in the jird, Meriones unguiculatus. Experimental Parasitology, 40, 438–446.CrossRefGoogle ScholarPubMed
Weiner, D. J. and Soulsby, E. J. L. (1976) Fate of Litomosoides carinii adults transplanted into the pleural or peritoneal cavity of infected and naive multi-mammate rats (Mastomys natalensis). Journal of Parasitology, 62, 887–894.CrossRefGoogle ScholarPubMed
Weiss, N. (1978) Dipetalonema viteae: In vitro blastogenesis of hamster spleen and lymph node cells to phytohemagglutinin and filarial antigens. Experimental Parasitology, 46, 283–299.CrossRefGoogle ScholarPubMed
Wong, M. M. (1974) Fate and immunogenicity of irradiated infective larvae of Dirofilaria immitis in the dog. In Proceedings of the Heartworm Symposium '74. (eds Morgan, H. C., Otto, G., Jackson, R. F., and Jackson, W. F). V. M. Publishing: North Nettleton Bonner Springs, Kansas.Google Scholar
Wong, M. M., Fredericks, H. J., and Ramachandran, C. P. (1969) Studies on immunization against Brugia malayi infection in the rhesus monkey. Bulletin of the World Health Organization, 40, 492–501.Google ScholarPubMed