Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-23T18:29:17.440Z Has data issue: false hasContentIssue false
  • English
  • Français

Eosinophilia in Ascaris suum-reinfected mice

Published online by Cambridge University Press:  05 June 2009

Kazuo Sugane
Kazuo Sugane
Affiliation:
Department of Parasitology, Faculty of Medicine, Shinshu University, 3–1–1 Asahi, Matsumoto City, Nagano Prefecture, Japan
Get access Rights & Permissions [Opens in a new window]

Abstract

The secondary response of eosinophilia has been studied in mice infected with A. suum. In mice infected orally with 1000 A. suum eggs, larvae disappeared from the body within two weeks after infection. The number of peripheral blood eosinophils decreased to the pre-infection level within eight weeks. A typical secondary response of IgG antibody production to egg antigen was found after reinfection with 1000 eggs. The number of peripheral blood eosinophils increased more rapidly after reinfection than after the primary infection. However, the peak number of eosinophils after reinfection was similar to that after primary infection, and the long-lasting characteristics of eosinophilia after reinfection did not differ from those after primary infection. These results suggest that the secondary response of eosinophilia is characterized by a rapid increase in the number of eosinophils in A. suum-reinfected mice.

Keywords

Ascaris suumeosinophiliamousesecondary responseIgG antibodyegg antigen
Type
Research Papers
Information
Journal of Helminthology , Volume 62 , Issue 1 , March 1988 , pp. 51 - 57
Copyright
Copyright © Cambridge University Press 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Ackerman, S. J., Gleich, G. J., Weller, P. F. & Ottensen, E. A. (1981) Eosinophilia and elevated serum levels of eosinophil major basic protein and Charcot-Leyden crystal protein (lysophospholipase) after treatment of patients with Bancroft's filariasis. Journal of Immunology, 127, 1093–1098.CrossRefGoogle ScholarPubMed
Ansari, A. & Williams, J. F. (1976) The eosinophilic response of the rat to infection with Taenia taeniaeformis. Journal of Parasitology, 62, 728–736.CrossRefGoogle ScholarPubMed
Bartelmez, S. H., Dodge, W. H. & Bass, D. A. (1980a) Differential regulation of spleen cell-mediated eosinophil and neutrophil-macrophage production. Blood, 55, 489–493.CrossRefGoogle ScholarPubMed
Bartelmez, S. H., Dodge, W. H., Mahmoud, A. A. F. & Bass, O. A. (1980b) Stimulation of eosinophil production in vitro by eosinophilopoietin and spleen cell-derived eosinophil growth-stimulating factor. Blood, 56, 706–711.CrossRefGoogle ScholarPubMed
Basten, A. & Beeson, P. B. (1970) Mechanism of eosinophilia. II. Role of lymphocyte. Journal of Experimental Medicine, 131, 1288–1305.CrossRefGoogle ScholarPubMed
Cline, M. J. & Golde, D. W. (1979) Controlling the production of blood cells. Blood, 53, 157–162.CrossRefGoogle ScholarPubMed
Discombe, G. (1946). Criteria of eosinophilia. Lancet, i, 195–196.CrossRefGoogle Scholar
Hillyer, G. V. & De Rios, I. G. (1979) The enzyme-linked immunosorbent assay (ELISA) for the immuno-diagnosis of schistosomiasis. American Journal of Tropical Medicine and Hygiene, 28, 237–241.CrossRefGoogle Scholar
Krupp, I. M. (1974) Hemagglutination test for the detection of antibodies specific for Ascaris and Toxocara antigens in patients with suspected visceral larva migrans. American Journal of Tropical Medicine and Hygiene, 23, 378–384.CrossRefGoogle ScholarPubMed
Metcalf, D., Parker, J., Chester, H. M. & Kincade, P. W. (1974) Formation of eosinophilic-like granulocytic colonies by mouse bone marrow cells in vitro. Journal of Cell Physiology, 84, 275–290.CrossRefGoogle ScholarPubMed
Oshima, T. (1961) Standardization of techniques for infecting mice with Toxocara canis and observations on the normal migration routes of larvae. Journal of Parasitology, 47, 652–656.CrossRefGoogle ScholarPubMed
Oshima, T. (1976) Observations of the age resistance, eosinophilia and larval behavior in helminth-free beagles infected with Toxocara canis. Japanese Journal of Parasitology, 25, 447–455.Google Scholar
Pincus, S. H., Cammarata, P. V., Delima, M. & Despommier, D. (1986) Eosinophilia in murine trichinellosis. Journal of Parasitology, 72, 321–325.CrossRefGoogle ScholarPubMed
Sprent, J. F. A. (1952) On the migratory behavior of the larvae of various Ascaris species in white mice. I. Distribution of larvae in tissues. Journal of Infectious Diseases, 90, 165–176.CrossRefGoogle ScholarPubMed
Sugane, K. & Oshima, T. (1980) Recovery of large numbers of eosinophils from mice infected with Toxocara canis. American Journal of Tropical Medicine and Hygiene, 29, 799–802.CrossRefGoogle ScholarPubMed
Sugane, K. & Oshima, T. (1982) Eosinophilia, granuloma formation and migratory behavior of larvae in the congenitally athymic mouse infected with Toxocara canis. Parasite Immunology, 4, 307–318.CrossRefGoogle ScholarPubMed
Sugane, K. & Oshima, T. (1983) Purification and characterization of excretory and secretory antigen of Toxocara canis larvae. Immunology, 50, 113–120.Google ScholarPubMed
Wong, H. S. W., Embil, J. A. & Ozere, R. L. (1976) Ascaris suum and Toxocara canis: Egg extract antigens in guinea pigs and macrophage migration inhibition test. Experimental Parasitology, 40, 421–426.CrossRefGoogle ScholarPubMed