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Enhancement of intestinal eosinophilia during Hymenolepis nana infection in mice

Published online by Cambridge University Press:  05 June 2009

A. Niwa  and
T. Miyazato
A. Niwa
Affiliation:
Department of Parasitology, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka 589, Japan
T. Miyazato
Affiliation:
Department of Parasitology, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka 589, Japan
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Abstract

The ability of Hymenolepis nana oncosphere extract to induce eosinophil chemotactic response was examined in vitro and in vivo. The extract showed a chemotactic activity specific for eosinophils but not for neutrophils. Partially purified eosinophil chemotactic factors (ECFs) from the oncosphere extract showed apparent molecular mass from 5.5 to 9.6kDa and 30 to 40kDa. These were resistant to heating and proteinase K digestion but sensitive to periodate oxidation. Peritoneal injection of the crude extract or partially purified ECFs to mice resulted in a preferential eosinophil infiltration. The chemotactic activity for eosinophils was not separable from the adhesion molecule expression or oxygen radical-inducing activity by means of chromatography or chemical treatments. Furthermore, histological examination demonstrated a marked tissue eosinophilia around H. nana larvae in the intestinal lamina propria of both humoral and cell-mediated immunodeficiency mice. The present findings suggest that H. nana oncosphere-derived molecules facilitate in vivo the intestinal eosinophilia during the infection.

Type
Research Papers
Information
Journal of Helminthology , Volume 70 , Issue 1 , March 1996 , pp. 33 - 41
Copyright
Copyright © Cambridge University Press 1996

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