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The effect of cyclosporin A on the course of Paragonimus miyazakii infection in rats

Published online by Cambridge University Press:  05 June 2009

Yoshihisa Hashiguchi  and
Yoshisuke Okamura
Yoshihisa Hashiguchi
Affiliation:
Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781–51, Japan
Yoshisuke Okamura
Affiliation:
Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781–51, Japan
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Abstract

The effect of the immunomodulatory fungal metabolite cyclosporin A (CyA) on the course of Paragonimus miyazakii infection in rats was studied. Administration of CyA 15 to 19 days post-infection resulted in a significantly lower recovery rate of worms and cyst formation in the host's lungs than in controls. Administration of CyA − 1 to + 3 days post-infection enhanced the growth and maturation of P. miyazakii, expressed as weight of worms and the number of worms with eggs in uteri with respect to control values. This study shows that administration of CyA to rats affects the host-parasite relationship, depending on the time of administration of the drug.

Keywords

Paragonimus miyazakiiratcyclosporin Ainfection course
Type
Research Papers
Information
Journal of Helminthology , Volume 62 , Issue 3 , September 1988 , pp. 251 - 256
Copyright
Copyright © Cambridge University Press 1988

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