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Cotugnia digonopora: carbohydrate metabolism and effect of anthelmintics on immature worms*

Published online by Cambridge University Press:  18 November 2009

N. A. Pampori ,
Govind Singh  and
V. M. L. Srivastava
N. A. Pampori
Affiliation:
Division of Biochemistry, Central Drug Research Institute, Lucknow-226001, India
Govind Singh
Affiliation:
Division of Biochemistry, Central Drug Research Institute, Lucknow-226001, India
V. M. L. Srivastava
Affiliation:
Division of Biochemistry, Central Drug Research Institute, Lucknow-226001, India
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Abstract

Cotugnia digonopora consumes, in 24 hours, glucose equivalent to 38% of its body-weight and converts it into metabolites. The Krebs' cycle is insignificant in the breakdown of glucose because very little CO2 is formed. Ether-cxtractablc acids account for most of the consumed sugar, confirming that metabolism is predominantly anaerobic. Glucose is assimilated as glycogen rather than as nucleic acids, lipids and proteins.

Niclosamidc, praziquantel and mebendazole strongly inhibit uptake of glucose by the parasite. A considerable increase in the production of lactic acid over that of ether-soluble and volatile acids under the influence of these drugs, suggests a rhange in the catabolism of sugar towards homolactate fermentation.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 1 , March 1984 , pp. 39 - 47
Copyright
Copyright © Cambridge University Press 1984

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