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Comparison of the live vaccine potential of different geographic isolates of Schistosoma mansoni

Published online by Cambridge University Press:  05 June 2009

Q. D. Bickle  and
M. J. Doenhoff
Q. D. Bickle
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Laboratories, 395 Hatfield Road, St Albans, Herts., AL40XQ, England
M. J. Doenhoff
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Laboratories, 395 Hatfield Road, St Albans, Herts., AL40XQ, England
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Abstract

We have investigated the capacity of irradiated larvae of each of six different isolates of Schistosoma mansoni to protect mice against challenge infections from the homologous or a different isolate. The isolates differed in respect of their geographic origins, and in the lengths of time they had been maintained in the laboratory. All isolates induced significant protection against unattenuated challenge infections, and neither the degree of geographic disimilarity between vaccinating and challenge parasites, nor the numbers of laboratory cycles, appeared to influence the degree of protection induced by irradiation-attenuated larvae.

Keywords

Schistosoma mansonigeographic isolatesmouseirradiated vaccine
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 3 , September 1987 , pp. 191 - 195
Copyright
Copyright © Cambridge University Press 1987

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References

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