Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-25T08:01:14.889Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparative efficacy of standard antihookworm drugs against various test nematodes

Published online by Cambridge University Press:  05 June 2009

Anuradha Misra ,
P. K. S. Visen  and
J. C. Katiyar
Anuradha Misra
Affiliation:
Division of Parasitology, Central Drug Research Institute, Lucknow-226001, India
P. K. S. Visen
Affiliation:
Division of Parasitology, Central Drug Research Institute, Lucknow-226001, India
J. C. Katiyar
Affiliation:
Division of Parasitology, Central Drug Research Institute, Lucknow-226001, India
Get access Rights & Permissions [Opens in a new window]

Abstract

The chemotherapeutic responses of three test nematodes, Nippostrongylus brasilietxsis, Nematospiroidesdubius and Ancylostoma ceylanicum to standard antihookworm drugs were assessed in order to select asuitable host-parasite system for the primary screening of potential antihookworm compounds. N. dubiusbehaved inconsistently and, with some infections, required more drug to achieve 100% clearance. Nippostrongylus brasiliensis was found to be sensitive to thiabendazole, tetramisole and levamisole but the broad spectrum anthclmintic mebendazole was ineffective. A. ceylanicum was very sensitive to mebendazole, sensitive to tetramisole and levamisole and refractory to thiabendazole. In vitro, none of the compounds had any lethal effect against any of the nematodes, except mebendazole against A. ceylanicum.

A. ceylanicum does occur in man and its chemotherapeutic reactions are similar to those of target hookworm infections of economic importance. As such, although not equally sensitive to standard anthelmintics, it is recommended for routine primary screening.

Type
Research Article
Information
Journal of Helminthology , Volume 55 , Issue 4 , December 1981 , pp. 273 - 278
Copyright
Copyright © Cambridge University Press 1981

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Broome, A. W.J.Greenhalgh, N. (1961) A New Anthelmintic With Unusual properties. Nature, 189, 59–60.CrossRefGoogle Scholar
Copp, F. C, Standen, O. D.Scarnwell, J., Rawes, D. A. & Burrow, R. B. (1958) A new scries of anthelmintics. Nature, 181, 183.CrossRefGoogle Scholar
Katiyar, J. C.Sen, A. B. (1969) A New Technique For Rapid Screening of potential ncmatocidal compounds. Indian Journal of Pharmacology, 31, 132–134.Google Scholar
Ray, D.K.Buopale, K. K. & Srivastava, V. B. (1972) Migration And Growth of Ahcylostoma ceylanicum in golden hamsters Mesocricetus auratus. Journal of llclminthology, 46, 357–362.CrossRefGoogle ScholarPubMed
Ray, D. K.Bhopale, K. K. & Srivastava, V. B. (1978) Efficacy Of Seven Anthelmintics against A ncylostoma ceylanicum in golden hamsters. Mesocricetus auratus. A nnals of Tropical Medicine and Parasitology, 72, 55–58.CrossRefGoogle Scholar
Sheffield, G.Meisenhelder, J. E. & Thompson, P. E.. (1959) The Effects of reference anthelmintics against N. dubius and oxyurids in mice relative to screening procedures for new drugs. Journal of Parasitology, 45, 653–658.CrossRefGoogle Scholar
Sen, A. B.Hawking, F. (1960) Screening Of Ccstocidal Compounds On A tapeworm Uymenolepis nana in vitro. British Journal of Pharmacology, 15, 436.Google ScholarPubMed
Standen, O. D. (1963) Chemotherapy Of Helminthic Infections. In: Experimental Chemotherapy (ed. Schnitzcr, R. J. and F., Hawking) 1, pp. 701. Academic Press; New York, London.CrossRefGoogle Scholar
Steward, J. S. (1955) Anthelmintic Studies: A Double Cntcroncmacidal Anthelmintic test covering a wide range of activities. Parasitology, 45, 242–254.CrossRefGoogle ScholarPubMed
Stone, O. J.Mullins., J. F. F. & Willis, C. C. (1965) In Vitro Studies On Ancylostoma caninum with abendazole with observations on larval exshcathment. Journal of Investigative Dermatology, 44, 256–258.CrossRefGoogle Scholar
Vouilloux, P. & Voelckel, J. (1957) Tctrachlorocthylcnc In The Treatment of Ancylostomiasis in children. Bulletin de la Societe de Pathologic Exolique, 50, 812–821.Google Scholar