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Attempts to manipulate specific responses to induce resistance to Schistosoma mansoni in Kenyan baboons (Papio anubis)

Published online by Cambridge University Press:  18 November 2009

R. F. Sturrock ,
A. E. Butterworth ,
V. Houba ,
B. J. cottrell ,
R. Kimani ,
M. Joseph ,
A. Capron ,
R. Ramasamy  and
J. Shah
R. F. Sturrock
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
A. E. Butterworth
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
V. Houba
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
B. J. cottrell
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
R. Kimani
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
M. Joseph
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
A. Capron
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
R. Ramasamy
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
J. Shah
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
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Abstract

Attempts were made to manipulate specific responses of baboons to protect them from infection with Schistosoma mansoni. In Experiment 1, cosinophilia was induced in naive baboons with Trichinella spiralis larvae given intravenously before intraperitoneal injection of globulin fractions from S. mansoni-infected baboon sera and subsequent percutancous exposure to S. mansoni cercariac. In Experiment 2, baboons with 8- or 32-week-old primary S. mansoni infections received T spiralis i.v. before an S. mansoni challenge. In experiments 3 to 5 respectively, naive baboons received intramuscularly before challenge: formalin-fixed S. mansoni schistosomula, with Bordetella pertussis as an adjuvant; a preparation of S. mansoni adult worm teguments; and a preparation of NE-immune complexes obtained from S. mansoni-infected rat sera, with Freunds Complete Adjuvant. Minor, but statistically insignificant, protection was obtained in Experiments 2 (32-week infections) and 3, but was far less than that given by intact, irradiated living vaccines. There are signs on the horizon of non-living vaccines protecting rodents against S. mansoni infection and it would be prudent, as with drugs, to test these in primates before proceeding to man. The results of our experiments, though essentially negative, should help the design of any future vaccine trials in primates.

Type
Research Article
Information
Journal of Helminthology , Volume 59 , Issue 2 , June 1985 , pp. 175 - 186
Copyright
Copyright © Cambridge University Press 1985

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