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The antifilarial activity of a novel group of organic arsenicals upon Brugia pahangi

Published online by Cambridge University Press:  05 June 2009

D. A. Denham ,
Sheree L. Oxenham ,
I. Midwinter  and
E. A. H. Friedheim
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT England
Sheree L. Oxenham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT England
I. Midwinter
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT England
E. A. H. Friedheim
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT England
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Abstract

Mel W is a second generation anionic organic arsenical which is filaricidal but has sporadic and unacceptable lethal side effects. Eight new cationic derivatives have now been synthesized in an attempt to avoid the side effects and have been examined for their effects upon adult Brugia pahangi in Meriones unguiculatus. They were all shown to be potent filaricides and the two best compounds, Mel Ga and Mel Cy, were at least 95% effective in killing adult B. pahangi at 5x3–13 mg/kg when injected subcutaneously.

Keywords

Brugia pahangiMeriones unguiculatusarsenicalsfilaricides
Type
Research Article
Information
Journal of Helminthology , Volume 60 , Issue 3 , September 1986 , pp. 169 - 172
Copyright
Copyright © Cambridge University Press 1986

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References

REFERENCES

Denham, D. A. (1982) Experience with a screen for macrofilaricidal activity using transplanted adult Brugia pahangi in the peritoneal cavities of Meriones unguiculatus. In: Animal Models in Parasitology, (editor, Owen, Dawn G.), pp. 93–104. Macmillan Press Ltd: London.CrossRefGoogle Scholar
Denham, D. A. & Fitzsimons, D. W. (1983) The filaricidal activity of some derivatives of N-[2-(4-thiazolyl) benzimidazole-5-yl]benzamide against Brugia pahangi adults. Methods and Findings in Experimental and Clinical Pharmacology, 5, 45–47.Google Scholar
Denham, D. A. & Mellor, P. (1976) The anthelmintic effects of a new compound “E” (Friedheim) on Onchocerca gutturosa in the cow—a possible tertiary screening system for drug action against O. volvulus in man. Journal of Helminthology, 50, 49–52.CrossRefGoogle ScholarPubMed
Denham, D. A., Samad, R., Cho, S-Y., Suswillo, R. R. & Skippins, S. C. (1979) The anthelmintic effects of flubendazole on Brugia pahangi. Transactions of the Royal Society of Tropical Medicine and Hygiene, 73, 673–676.CrossRefGoogle ScholarPubMed
Denham, D. A., Suswillo, R. R., Rogers, R., Mcgreevy, P. B. & Andrews, B. J. (1976) Studies on Brugia pahangi. 13. The anthelmintic effect of compounds F151 (Friedheim), HOE 33258 (Hoechst) and their reaction product. Journal of Helminthology, 50, 243–250.CrossRefGoogle ScholarPubMed
Friedheim, E. A. H. (1961) Quelques observations concernant Ie pentyl-thiarsaphenyl-melamine (Mel W) dans Ie traitement des filarioses à O. volvulus et W. bancrofti. Annales de la Société Beige de Médecine Tropicale, 4, 367–373.Google Scholar
Friedheim, E. A. H. (1962a) Mel W in the treatment of filariasis due to W. bancrofti: Results in 35 cases observed for 10–12 months after treatment. Annals of Tropical Medicine and Parasitology, 56, 337–342.CrossRefGoogle Scholar
Friedheim, E. A. H. (1962b) Mel W in the treatment of onchocerciasis in leprosy patients: Results in 12 cases observed for 20 months after treatment. Annals of Tropical Medicine and Parasitology, 56, 343–351.CrossRefGoogle ScholarPubMed
Friedheim, E. A. H. (1974) Therapeutic field trial of a macro- and micro-filaricidal agent in canine filariasis. Bulletin of the World Health Organization, 50, 572–574.Google Scholar
Friedheim, E. A. H. & De Jongh, R. T. (1959) L'effet du pentylthiarsaphenylmelamine (Mel W) sur W. bancrofti. Bulletin de la Société de Pathologie Exotique, 52, 785–791.Google Scholar
Friedheim, E. A. H. & De Jongh, R. T. (1960) Deux observations d'effets the“rapeutiques dans l'onchocercose apres un traitement au Mel W et au TWSb. Bulletin de la Société de Pathologie Exotique, 53, 43–46.Google Scholar
Goodwin, L. G. (1984) Chemotherapy. In: Recent Advances in Research on Filariasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 78 (Suppl.), 1–8.CrossRefGoogle Scholar
Soulsby, E. J. L. (1968) Helminths, Arthropods and Protozoa of Domesticated Animals. Bailliere, Tindall and Cassell Ltd.: London.Google Scholar
Suswillo, R. R. & Denham, D. A. (1977) A new system of testing for filaricidal activity using transplanted adult Brugia in the jird. Journal of Parasitology, 63, 591–592.CrossRefGoogle ScholarPubMed