Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-25T08:09:02.703Z Has data issue: false hasContentIssue false
  • English
  • Français

Anticestode activity of 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate—a preliminary report*

Published online by Cambridge University Press:  05 June 2009

Suman Gupta ,
J. C. Katiyar ,
A. B. Sen ,
S. K. Dubey ,
H. Singh ,
S. Sharma  and
R. N. Iyer
Suman Gupta
Affiliation:
Division of parasitology, Central Drug Research Institute, Lucknow-226001, India
J. C. Katiyar
Affiliation:
Division of parasitology, Central Drug Research Institute, Lucknow-226001, India
A. B. Sen
Affiliation:
Division of parasitology, Central Drug Research Institute, Lucknow-226001, India
S. K. Dubey
Affiliation:
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
H. Singh
Affiliation:
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
S. Sharma
Affiliation:
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
R. N. Iyer
Affiliation:
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
Get access Rights & Permissions [Opens in a new window]

Extract

Many compounds have been claimed to possess powerful taenicidal activity but only a few are able to remove the tapeworms complete with scolices; accordingly better drugs are still needed. A series of 3, 5-dibromosalicylanilides, possessing a molecular framework similar to that of niclosamide (Gönnert and Schraufstätter, 1960) was tested for taenicidal activity; the most potent anticestode compound was found to be 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate (CDRI Compound 77–6). The present communication compares the efficacy of Compound 77–6 with niclosamide, N-(2' -chloro-4-nitrophenyl)-5-chlorosalicylamid (Bayer, power with 75% active ingredient) and praziquantel, 2-cyclohexylcarbonyl-1–3, 4, 6, 7, 11 b-hexahydro-2H-Pyrazino [2–1-a], isoquinoline-4-one (Droncit, E. Merck & Bayer, powder, 100% pure) (Seubert et al., 1977) in rats and mice.

Type
Research Note
Information
Journal of Helminthology , Volume 54 , Issue 4 , December 1980 , pp. 271 - 273
Copyright
Copyright © Cambridge University Press 1980

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bushby, S. R. M. (1963) Toxicity in chemotherapy. In Experimental chemotherapy (ed. Schnitzer, R. J. and Hawking, F.) Vol. 1, pp. 25–53. Academic Press, New York and London.CrossRefGoogle Scholar
Gönnert, R. and Schraufstätter, E. (1960) Experimentelle Untersuchungen mit (N-2’ -chlor-4’ -nitrophenyl)-5-chlorosalicylamid, einem neuen Bandwurmmittel. Arzneimittel Forschung, 10, 881–884.Google Scholar
Gönnert, R., Johannis, J.., Schraufstätter, E. and Sturfe, R. (1963) Konstitution und cestocide Wirkung in der Yomesan-Reihe. Medicinal Chemistry (Bayer, Leverkusen, Germany), 7, 540–568.Google Scholar
Seubert, J.., Pohlke, R. and Loebich, F. (1977) Synthesis and properties of praziquantel, a novel broad spectrum anthelmintic with excellent activity against schistosomes and cestodes. Experientia, 33, 1036–1037.CrossRefGoogle ScholarPubMed
Steward, J. S. (1955). Anthelmintic studies: A taenicidal testing technique. Parasitology, 45, 255–265.CrossRefGoogle Scholar