Hostname: page-component-7bb8b95d7b-cx56b Total loading time: 0 Render date: 2024-09-13T02:09:02.005Z Has data issue: false hasContentIssue false
  • English
  • Français

An evaluation of ethyl-6-ethoxybenzothiazole-2-carbamate (Sch 18099) for anthelmintic activity in domestic animals

Published online by Cambridge University Press:  05 June 2009

Eric Panitz
Eric Panitz
Affiliation:
The Schering Corporation Animal Health Research Center, Allentown, New Jersey 08501, USA
Get access Rights & Permissions [Opens in a new window]

Abstract

Ethyl-6-ethoxybenzothiazole-2-carbamate (Sch 18099) was evaluated for efficacy against natural helminth infections in ponies, pigs, lambs and chickens.

Sixteen critical trials were conducted in ponies at dosages of 15 to 150 mg/kg. At 15 mg/kg, efficacy against adult and larval Oxyuris equi was 100% and 91% and against small strongyles it was 98%. Efficacy levels were >95% against Strongylus vulgaris and S. edentatus at the 20 mg/kg dosage. In two trials at 100 mg/kg efficacy against Parascaris equorum was 77%. No efficacy was observed against Gastrophilus spp. or Anoplocephala spp.

In swine single oral doses of 10 to 100 mg/kg were not effective. 500 ppm Sch 18099 in the diet for seven days resulted in 100% efficacy against Ascaris suum and Trichuris suis but had no effect on Strongyloides ransomi. Efficacy at 250 ppm against A. suum was 77%.

Efficacy at 200 mg/kg in lambs was >90% for Haemonchus contortus, Trichostrongylus axei, Marshallagia marshalli, Bunostomum trignocephalum, Oesophagostomum columbianum, Trichuris ovis, and Chabertia spp. Efficacy was <80% for Trichostrongylus vitrinus, Nematodirus filicollis, Ostertagia circumcinta and Cooperia curticei. Except for O. circumcinta and C. curticei, drug efficacy was reduced for these worms in lambs treated at 100 mg/kg.

Efficacies of 14˙3–89% against Ascaridia galli were obtained with dietary levels of 125–1000 ppm Sch 18099 fed for 7 days. Efficacy of 100% was recorded against Heterakis gallinarum at the 1000 ppm dietary drug level.

Type
Research Article
Information
Journal of Helminthology , Volume 51 , Issue 1 , March 1977 , pp. 23 - 30
Copyright
Copyright © Cambridge University Press 1977

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Baeder, C., Bahr, H., Christ, O., Düwel, D., Kellner, H. M., Kirsch, R., Loewe, H., Schultes, E., Schutz, E. and Westen, H. (1975) Fenbendazole: A new, highly effective anthelmintic. Experientia, 30, 753–54.CrossRefGoogle Scholar
Batte, E. G. and Moncol, D. J. (1968) Evaluation of parbendazole, a new broad spectrum anthelmintic for swine and sheep VM/SAC, 63, 984–985.Google ScholarPubMed
Bradley, R. E. and Radhakrishnan, C. V. (1973) Critical test evaluation of Mebendazole against gastrointestinal parasites of horses and ponies. American Journal of Veterinary Research, 34, 475–477.Google ScholarPubMed
Kates, K. C., Colglazier, M. C. and Enzie, F. D. (1969) Comparative efficacy of levo-tetramisole, parbendazole and piperazine citrate against some common helminths of turkeys. Transactions of the American Microscopical Society, 88, 142–148.CrossRefGoogle ScholarPubMed
Theodorides, V. J. and Chang, J. (1973) Oxibendazole, a new effective anthelmintic against the gastrointestinal nematodes of sheep. Paper presented at the 1973 meeting of Midwestern Animal Disease Research Workers (Chicago, Illinois).Google Scholar
Theodorides, V. J., Chang, J., Dicuollo, C. J., Grass, G. H., Parish, R. C. and Scott, G. C. (1973) Oxibendazole, a new broad spectrum anthelmintic effective against gastrointestinal nematodes of domestic animals. British Veterinary Journal, 199, xcvii–xcviii.Google Scholar