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Allergic reactivity and IgG subclasses to a proteinase fraction of Setaria digitata in filariasis

Published online by Cambridge University Press:  05 June 2009

M.K. Beuria ,
M. Bal  and
M.K. Das
M.K. Beuria
Affiliation:
Parasite Immunology Division, Regional Medical Research Centre (ICMR), Nandankanan Road, Bhubaneswar 751 016, India
M. Bal
Affiliation:
Parasite Immunology Division, Regional Medical Research Centre (ICMR), Nandankanan Road, Bhubaneswar 751 016, India
M.K. Das*
Affiliation:
Parasite Immunology Division, Regional Medical Research Centre (ICMR), Nandankanan Road, Bhubaneswar 751 016, India
*
* Author for correspondence.
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Abstract

A low molecular weight fraction (30 KDa) of the cattle filarial parasite Setaria digitata that was earlier demonstrated to have allergenic activity was characterized to be a zinc-dependent cysteine proteinase. Immediate type hypersensitivity (ITH) reaction to the proteinase was evaluated in lymphatic filariasis patients and in endemic controls from Orissa, India. The extent of ITH positivity to the proteinase in infected individuals ranged from 20% in chronic filariasis (CP) patients group to 56% in asymptomatic microfilaraemic carriers (AS). About 62% of endemic normals (EN) were also ITH positive. The serum levels of IgG subclasses were compared in ITH positive and ITH negative filarial patients (AS and CP) as well as in endemic normals (EN) respectively. IgG4 levels were found to be inversely dependent on ITH reaction only in AS groups. Asymptomatic patients (AS) with positive ITH reactivity had lower IgG4 than ITH negative individuals from the same group. The serum levels of other IgG subclasses except IgG2 did not correlate with ITH reactivity. IgG2 levels were higher in ITH negative EN and CP patients but not in the AS group.

Type
Research Papers
Information
Journal of Helminthology , Volume 69 , Issue 3 , September 1995 , pp. 181 - 185
Copyright
Copyright © Cambridge University Press 1995

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