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Vaccination with hatched but non-activated, non-viable oncospheres of Taenia taeniaeformis in rats

Published online by Cambridge University Press:  05 June 2009

A. Ito  and
A. Hashimoto
A. Ito
Affiliation:
Department of Parasitology, Gifu University School of Medicine, Gifu 500
A. Hashimoto
Affiliation:
Veterinary Hospital, Faculty of Agriculture, Gifu University, Gifu 501, Japan
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Abstract

The usefulness of hatched but non-activated oncospheres as a candidate vaccine was evaluated using a Taenia taeniaeformis/rat system, since preparation of these oncospheres in vitro is known to be very simple. The findings were: (1) rats vaccinated with non-viable oncospheres became completely resistant to challenge infection; (2) intra-venous injection was the most effective to induce complete resistance; (3) a single oncosphere was sufficient to induce complete resistance in infected rats, whereas approximately 50 and 500 non-viable oncospheres were required to evoke strong and complete resistance, respectively, in vaccinated rats. The usefulness of non-viable oncospheres without adjuvant is discussed.

Keywords

Taenia taeniaeformisvaccinationnon-viable oncospheresratCestoda
Type
Research Note
Information
Journal of Helminthology , Volume 67 , Issue 2 , June 1993 , pp. 165 - 168
Copyright
Copyright © Cambridge University Press 1993

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