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The suppression of homologous immunity by soluble adult antigens of Nematospiroides dubius

Published online by Cambridge University Press:  18 November 2009

D. I. Pritchard  and
J. M. Behnke
D. I. Pritchard
Affiliation:
M.R.C. Experimental Parasitology Group, Department of Zoology, University of Nottingham, Nottingham NG7 2RD, UK
J. M. Behnke
Affiliation:
M.R.C. Experimental Parasitology Group, Department of Zoology, University of Nottingham, Nottingham NG7 2RD, UK
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Abstract

An established adult infection of Nematospiroides dubius was unaffected by the administration of immune lymphocytes and immune sera whereas an incoming larval infection was expelled. Past experiments have shown that the immune inoculum at least had the ability to recognize adult stages, leading to the hypothesis that adult stages secrete or excrete an immunomodulatory shield around themselves in the gastrointestinal tract. This hypothesis was given further credence by the demonstration that soluble antigens derived from adults abolished the generation of homologous immunity to this parasite. Modulation of immunity was reflected by increased fecundity, increased worm size, and increased survival time in the gut.

Type
Research Article
Information
Journal of Helminthology , Volume 59 , Issue 3 , September 1985 , pp. 251 - 256
Copyright
Copyright © Cambridge University Press 1985

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References

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