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Studies of potential filaricides: Part 14—Activity of l-iso-butoxycarbonyl-4-methyIpiperazine against experimental filariasis*

Published online by Cambridge University Press:  05 June 2009

R. Rastogi ,
S. Sharma ,
N. Anand ,
A. Dutta ,
N. Fatma ,
R. K. Chatterjee  and
A. B. Sen
R. Rastogi
Affiliation:
Medical Chemistry Division
S. Sharma
Affiliation:
Medical Chemistry Division
N. Anand
Affiliation:
Medical Chemistry Division
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Abstract

The synthesis and filaricidal activity of l-iso-butoxycarbonyl-4-mcthylpipcrazinc against Litomosoides carinii in Sigmodon hispidus and Dipctaloncma viteae in Mastomys natalcnsis is reported. At an intrapcritoncal or oral dose of 3 mg/kg given for 6 days, the compound removed 91% of the circulating microfilariac but had no effect on adult L carinii. However, it killed all microfilariae and adults of D. viteae at a subcutaneous dose of 50 mg/kg given for 6 days. The compound also possessed ehemoprophylaetic activity against the larvae of L. carinii and D. viteae at a dose of 30 and 50 mg/kg respectively.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 3 , September 1984 , pp. 251 - 254
Copyright
Copyright © Cambridge University Press 1984

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References

REFERENCES

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