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Prolonged expulsion of adult Trichinella spiralis and eosinophil infiltration in mast cell-deficient W/Wv mice

Published online by Cambridge University Press:  18 November 2009

M. Kamiya ,
Y. Oku ,
H. Itayama  and
M. Ohbayashi
M. Kamiya
Affiliation:
Department of Parasitology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
Y. Oku
Affiliation:
Department of Parasitology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
H. Itayama
Affiliation:
Department of Parasitology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
M. Ohbayashi
Affiliation:
Department of Parasitology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
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Abstract

Eosinophil infiltrations were observed in the intestine and the muscle of both Trichinella spiralis-infected (WBxC57BL/6)F1-W/Wv mice and their littermates, WBB6F1−+/+, +/W, +/Wv, almost to the same extent. W/Wv mice did not show infiltration of subepithelial mast cells and globule leucocytes in response to T. spiralis infection. Increased numbers of these cells were observed in their littermates. Worms in W/Wv mice were retained for longer periods than those in littermates. Also, no difference was noted in the production of specific serum antibodies between W/Wv mice and their littermates, as determined by passive cutaneous anaphylaxis (PCA) for specific IgE and by indirect haemagglutination (IHA). These results suggest a possible participation of SMC, GL and eosinophils in the expulsion of adult T. spiralis.

Type
Research Article
Information
Journal of Helminthology , Volume 59 , Issue 3 , September 1985 , pp. 233 - 239
Copyright
Copyright © Cambridge University Press 1985

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