Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-23T16:12:05.223Z Has data issue: false hasContentIssue false
  • English
  • Français

The pathogenesis of benzimidazole-resistant and benizimidazole-susceptible strains of trichostrongylus colubriformis in the Mongolian gerbil (Meriones unguiculatus)

Published online by Cambridge University Press:  05 June 2009

John M. Maclean ,
David lewis  and
Peter H. Holmes
John M. Maclean
Affiliation:
Department of Veterinary Physiology, University of Glasgow Veterinary School, Bearsden Road, Glasgow, Scotland, U.K.
David lewis
Affiliation:
Pfizer Central Research, Sandwich, Kent, England, U.K.
Peter H. Holmes
Affiliation:
Department of Veterinary Physiology, University of Glasgow Veterinary School, Bearsden Road, Glasgow, Scotland, U.K.
Get access Rights & Permissions [Opens in a new window]

Abstract

Mongolian gerbils were infected with either a benzimidazole-susceptible or a benzimidazole-resistant strain of Trichostrongylus colubriformis larvae. The comparative pathogensis of both strains of T. colubriformis was investigated for 50 days post-infection. The gerbils infected with the drug-susceptible strain of the parasite showed lower survival rates, reduced body weights, higher parasite egg output and higher worm burdens than animals intected with the drug-resistant stram of parasite. There was also evidence of an enhanced hypoalbuminaemia and a more marked gastrointestinal plasma leak in the gerbils infected with the drug-susceptible strain of patasite. Scanning electron microscope examination of the small intestine showed signs of villus atriphy in both groups of ingected grebils.

Keywords

PathogenesisTrichostrongylus colubriformisMeriones unguiculatusbenzimidazole resistance
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 2 , June 1987 , pp. 179 - 189
Copyright
Copyright © Cambridge University Press 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Barker, I. K. (1973a) A study of the pathogenesis of Trichostrongylus colubriformis infection in lambs with observations on the contribution of gastrointestinal plasma loss. International Journal for parasitology, 3, 743–757.CrossRefGoogle ScholarPubMed
Barker, I. K. (1973b) Scanning electron microscopy of the duodenal mucosa of lambs infected with Trichostrongylus colubriformis. Parasitology, 67, 307–314.CrossRefGoogle ScholarPubMed
Coop, R. L. & Angus, K. W. (1975). The effect of continuous doses of Trichostronogylus colubriformis larvae on the intestinal mucosa of sheep and on liver vitamin A concentration. Patasitology, 70, 1–9.CrossRefGoogle ScholarPubMed
Drudge, J. H., Leyland, S. E. & Wyant, Z. M. (1957) Strain variation in the response of sheep nematodes to the action of phenothiazine. II. Studies on pure infections of Haemonchus contortus. American Journal of Veteribary Research, 18, 317–325.Google Scholar
Kelly, J. D., Whitlock, H. V. & Thompson, H. G. (1978) Physiological characteristics of free-living and parasitic stages of strians of Haemonchus contortus susceptible or resistant to benzimidazole anthelmintics. Reserch in Veterinary Science, 25, 367–385.Google Scholar
Maclean, J. M., Lewis, D. & Holmes, P. H. (1987) Studies on the pathogenesis of Trichostrongylus colubriformis in Mongolian gerbils (Meriones unguiculatus). Journal of Comparative Pathology, in press.CrossRefGoogle ScholarPubMed
Martin, J. (1980) Scanning electron microscope studies of the small intestine of rats maintained on a low protein diet and infected with Nippostrongylus brasiliensis. Parasitology, 80, 39–47.Google Scholar
Poppi, D. P., MacRae, J. C., Corrigal, W. & Coop, R. L. (1981) Nitrogen digestion in sheep infected with intestinal parasites. Proceeding of the Nutrition Society, 40, 116Ap.Google Scholar
Prichard, R. K., Kelly, J. D. & Thompson, H. G. (1978) The effects of benzimidazole resistance and route of administration on the uptake of fenbendazole and thiabendazole by Haemonchus contortus and Trichostrongylus colubriformis in sheep. veternary. Parasitology, 4, 243–255.Google Scholar
Shayo, M. E. & Benz, G. W. (1979) Histopathologic and histochemichanges in the small intestine of calves infected with Trichistrongylus colubriformis. Veterinary Parasitology, 5, 353–364.Google Scholar
Steel, J. W., Symons, L. E. A. & Jones, W. O. (1980) Effects of level intake on the productivity and physiological and metabolic responses of lambs infected with Trichostrongylus colubriformis. Australian Journal of Agricultural Research, 31, 821–838.Google Scholar
Walker-smith, J. A., Skyring, A. P. & Mistilis, S. P. (1967) Use of 51CrCl3 in the diagnosis of protein-losing enteropathy. Gut, 8, 166–168.Google Scholar