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The pathogenesis of a single challenge dose of Haemonchus contortus in lambs under six months of age

Published online by Cambridge University Press:  18 November 2009

A. R. Hunter  and
Grace Mackenzie
A. R. Hunter
Affiliation:
Ministry of Agriculture, Fisheries and Food, Veterinary Laboratory, Eskgrove, Lasswade, Midlothian, Scotland
Grace Mackenzie
Affiliation:
Ministry of Agriculture, Fisheries and Food, Veterinary Laboratory, Eskgrove, Lasswade, Midlothian, Scotland
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Abstract

The pathogenesis of H. contortus infection in lambs under 6 months of age challenged orally with 10,000 third stage infective larvae is described. The development of the parasite and its relationship to haematological and pathological changes are discussed, with particular reference to specific cellular mobilizations, and detailed descriptions are given of the haematology and parasitology, gross pathology and histopathology at 4, 7, 12, 18, 22 and 35 days after infection. Dramatic changes had developed by day 12.

Type
Research Papers
Information
Journal of Helminthology , Volume 56 , Issue 2 , June 1982 , pp. 135 - 144
Copyright
Copyright © Cambridge University Press 1982

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References

REFERENCES

Andrews, J. S. (1942) Stomach worms (Haemonchus contortus) infection in lambs and its relation to gastric haemorrhage and general pathology. Journal of Agricultural Research, 65, 1–18.Google Scholar
Archer, R. K. (1959) Eosinophil leucocytes and their reactions to histamine and 5-hydroxytryptamine. Journal of Pathology and Bacteriology, 78, 95–103.CrossRefGoogle ScholarPubMed
Archer, R. K. (1963) The Eosinophil Leucocyte. 1st edition. Blackwell, Oxford.Google Scholar
Charleston, W. A. G. (1965) Pathogenesis of experimental haemonchosis in sheep, with special reference to the development of resistance. Journal of Comparative Pathology, 75, 55–67.CrossRefGoogle Scholar
Dargie, J. D. & Allonby, E. W. (1975) Pathophysiology of single and challenge infections of Haemonchus contortus in Merino sheep; studies on red cell kinetics and the “self-cure” phenomenon. International Journal for Parasitology, 5, 147–157.CrossRefGoogle ScholarPubMed
Fourie, P. J. J. (1931) The haematology and pathology of haemonchosis in sheep. Union of South Africa Department of Agriculture Disease, Veterinary Service and Animal Industry Report 17; 495–572.Google Scholar
Litt, M. (1961) Studies in experimental eosinophilia. III. The induction of peritoneal eosinophilia by the passive transfer of serum antibody. Journal of Immunology, 87, 522–529.CrossRefGoogle ScholarPubMed
Misra, S. C. & Ruprah, N. S. (1972) Haemonchus contortus infection in experimental lambs. Indian Veterinary Journal, 49, 554–560.Google Scholar
Murray, M. (1972) In: Immunity to animal parasites. Academic Press, New York.Google Scholar
Ransom, B. H. (1906) The life history of the twisted wire worm (Haemonchus contortus) of sheep, cattle and other ruminants. Circular 93, U.S.D.A. Bureau Animal Industry, 1–7.Google Scholar
Roberts, F. H. S. & O'Sullivan, P. J. (1950) Methods for egg counts and larval cultures for strongylcs infesting the gastro-intestinal tract of cattle. Australian Journal of Agricultural Research, 1, 99–102.CrossRefGoogle Scholar
Rothwell, T. L. W. & Love, R. J. (1975) Studies of the responses of basophil and cosinophil leucocytes and mast cells to the nematode Trichostrongylus columbriformis. II. Changes in cell numbers following infection of thymectomiscd and adoptively or passively immunized guinea pigs. Journal of Pathology, 116, 183–194.CrossRefGoogle Scholar
Ross, J. G. (1963) Experimental infections of calves with the nematode parasite Ostertagia ostertagi, Veterinary Record, 75, 129–131.Google Scholar
Silverman, P. H. & Patterson, J. E. (1960) Histotrophic (parasitic) stages of Haemonchus contortus. Nature, 185, 54–55.CrossRefGoogle ScholarPubMed
Smith, W. D. & Angus, K. W. (1980) Haemonchus contortus; attempts to immunize lambs with irradiated larvae. Research in Veterinary Science, 29, 45–50.CrossRefGoogle ScholarPubMed
Sommerville, R. I. (1956) The histology of the ovine abomasum, and the relation of the globule leucocyte to nematode infestations. Australian Veterinary Journal, 32, 237–240.CrossRefGoogle Scholar
Soulsby, E. J. L. (1962) In: Animal Health and Production. 1st Edition. Butterworths, London.Google Scholar
Stoll, N. R. (1943) The wanderings of Haemonchus in the sheep host. Journal of Parasitology, 29, 407–416.CrossRefGoogle Scholar
Urquhart, G. N., Jarrett, W. F. H., Jennings, F. W., McIntyre, W. I. M. & Mulligan, W. (1966) Immunity to Haemonchus contortus infection; relationship between age and successful vaccination with irradiated larvae. American Journal Veterinary Research, 27, 1645–1648.Google ScholarPubMed
Veglia, F. (1915) The anatomy and life history of the Haemonchus contortus. Report Veterinary Research South Africa, 3 & 4, 347–500.Google Scholar
Wakelin, D. (1978) Immunity to intestinal parasites. Nature, 273, 617–620.CrossRefGoogle ScholarPubMed
Whur, P. (1966) Relationship of globule leucocytes to gastro-intestinal nematodes in the sheep, and Nippostrongylus hrasiliensis and Hymenolepis nana infections in rats. Journal of Comparative Pathology, 76, 57–65.CrossRefGoogle Scholar