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Immunological Studies on Experimental Infection of Guineapigs and Rabbits with Ascaris suum Goeze, 1782. II. —Antibody Production and the Further Demonstration of Acquired Resistance in Guineapigs*

Published online by Cambridge University Press:  18 November 2009

L. F. Taffs
L. F. Taffs
Affiliation:
Department of Animal Pathology, School of Veterinary Medicine, Cambridge**
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Extract

Guineapigs infected by mouth with eggs of A. suum developed an acquired resistance to reinfection 27, 35 and 51 days later. Resistance of the host was manifested by: survival following a lethal dose of eggs; an inhibition of larval migration; a retardation of larval growth; and the ability to maintain or gain weight.

By means of the conglutinating complement absorption test, using a saline extract of worm as antigen, antibodies were detected in the serum of resistant guineapigs seven days after the second reinfection. Antibodies were not detected in the serum of nonresistant guineapigs seven days after one infection. There was some evidence to indicate that the conglutinating antibody titre of the serum is a measure of the host's ability to resist infection.

Type
Research Papers
Information
Journal of Helminthology , Volume 38 , Issue 3-4 , December 1964 , pp. 315 - 324
Copyright
Copyright © Cambridge University Press 1964

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