Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-25T05:33:06.421Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunity to tapeworms: acquired resistance to Hymenolepis citelli in the mouse

Published online by Cambridge University Press:  05 June 2009

Sidit. O. Alghali
Sidit. O. Alghali
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden Glasgow Scotland U.K.
Get access Rights & Permissions [Opens in a new window]

Abstract

The dynamics of secondary infections with Hymenolepis citelli in mice are described. A primary infection of one and six cysticercoids for 21 days sensitized CFLP male mice against homologous challenge infections. Acquired resistance was manifested mainly as stunting/destrobilation of secondary worms. The severity of stunting depended on the intensity of the primary infection. Secondary worms were not expelled more rapidly than primary worms but the protective response retards growth early in challenge infections. Sensitization of mice for seven days with six or 24 cysticercoids did not confer a measurable protective response, whereas priming by the same regime for 21 days induced a significant Protective response. Acquired resistance to challenge waned with time in the absence of the primary Worms. The growth and survival of a six-cysticercoid primary infection was enhanced by the administration of the immunosuppressant drug cortisone acetate. Worms from cortisone-treated mice Were heavier than those from untreated controls. Acquired resistance to homologous challenge was also Partially ablated in cortisone-treated mice. It is suggested that rejection of primary infections and stunting/destrobilation of secondary worms may be immunologically mediated.

Keywords

Hymenolepis citellimouseacquired resistancecortisone.
Type
Research Article
Information
Journal of Helminthology , Volume 60 , Issue 3 , September 1986 , pp. 219 - 233
Copyright
Copyright © Cambridge University Press 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Alghali, S. T. O. (1980) Intestinal immunity to tapeworms: The rejection of Hymenolepis citelli by mice and rats. Ph.D. Thesis, University of Glasgow.Google Scholar
Befus, A. D. (1975a) Secondary infections of Hymenolepis diminuta in mice: effects of varying worm burdens in primary and secondary infections. Parasitology, 71, 61–75.CrossRefGoogle ScholarPubMed
Befus, A. D. (1975b) Intestinal immune responses of mice to the tapeworms Hymenolepis diminuta and H. microstoma. Ph.D. Thesis, University of Glasgow.Google Scholar
Befus, A. D. & Featherston, D.W. (1974) Delayed rejection of single Hymenolepis diminuta in primary infections of young mice. Parasitology, 69, 77–85.CrossRefGoogle ScholarPubMed
Bell, R. G., Mcgregor, D. D. & Despommier, D.D. (1979) Trichinella spiralis: Mediation of the intestinal component of protective immunity in the rat by multiple, phase-specific, antiparasitic responses. Experimental Parasitology, 47, 140–157.CrossRefGoogle ScholarPubMed
Christie, P. R. (1979) The intestinal immune response of the mouse to the tapeworm Hymenolepis diminuta. Ph.D. Thesis, University of Glasgow.Google Scholar
Claman, N. H. (1975) How corticosteroids work. Journal of Allergy and Clinical Immunology, 55, 145–151.CrossRefGoogle ScholarPubMed
Despommier, D. (1977) Immunity to Trichinella spiralis. American Journal of Tropical Medicine and Hygiene, 26, 68–75.CrossRefGoogle ScholarPubMed
Dracott, B. N. & Smith, C.E. T. (1979) Hydrocortisone and the antibody response in mice. 1. Correlations between serum cortisol levels and cell numbers in thymus, spleen, marrow and lymph nodes. Immunology, 28, 429–435.Google Scholar
Elowni, E. E. (1980) Immunity to tapeworms: vaccination against Hymenolepis diminuta and the role of the bursa of Fabricius in rejection of Raillietina cesticillus. PhD. Thesis, University of Glasgow.Google Scholar
Elowni, E. E. (1982) Hymenolepis diminuta: Origin of the protective antigens. Experimental Parasitology, 53, 157–163.CrossRefGoogle ScholarPubMed
Feldbush, T. L. (1973) Antigen modulation of the immune response. The decline of immunological memory in the absence of continuing antigenic stimulation. Cellular Immunology, 8,435–444.CrossRefGoogle ScholarPubMed
Grencis, R. K., Lee, T. D. G. & Wakelin, D. (1985) Adoptive transfer of immunity to Trichinella spiralis in mice: Generation of effective cells by different life stages. International Journal for Parasitology, 15, 195–202.CrossRefGoogle Scholar
Grencis, R. K. & Wakelin, D. (1982) Short lived, dividing cells mediate adoptive transfer of immunity to Trichinella spiralis in mice. 1. Availability of cells in primary and secondary infections in relation to cellular changes in the mesenteric lymph node. Immunology, 46, 443–450.Google Scholar
Hopkins, C. A. (1980) Immunity and Hymenolepis diminuta. In: Biology of the Tapeworm Hymenolepis diminuta (editor Arai, H. P.), pp. 551–614. Academic Press: New York.CrossRefGoogle Scholar
Hopkins, C. A. & Barr, I. (1982) The source of antigen in an adult tapeworm. International Journal of Parasitology, 12, 327–333.CrossRefGoogle Scholar
Hopkins, C. A., Grant, P. M. & Stallard, H.E. (1973) The effect of oxyclozanide on Hymenolepis microstoma and H. diminuta. Parasitology, 66, 355–365.CrossRefGoogle ScholarPubMed
Hopkins, C. A. & Stallard, H.E. (1974) Immunity to intestinal tapeworms: the rejection of Hymenolepis citelli by mice. Parasitology, 69, 63–76.CrossRefGoogle ScholarPubMed
Hopkins, C. A. & Stallard, H.E. (1976) The effect of cortisone on the survival of Hymenolepis diminuta in mice. Rice University Studies, 62, 145–159.Google Scholar
Hopkins, C. A., Subramanian, G. & Stallard, H.E. (1972) The development of Hymenolepis diminuta in primary and secondary infections in mice. Parasitology, 64,401–412.CrossRefGoogle ScholarPubMed
Howard, R. J. (1976a) The growth of secondary infections of Hymenolepis microstoma in mice: the effect of various primary infection regimes. Parasitology, 72, 317–323.CrossRefGoogle ScholarPubMed
Howard, R. J. (1976b) Aspects of the host⁄parasite relationship of Hymenolepis microstoma. PhD. Thesis, University of Glasgow.Google Scholar
Lee, T. D. G. & Wakelin, D. (1982) Cortisone-induced immunotolerance to nematode infection in CBA⁄ca mice. 1. Investigation of the defect in the protective response. Immunology, 47, 227–232.Google Scholar
Mantzouranis, E. & Borel, Y. (1979) Different effects of cortisone on the humoral immune response to T-dependent and T-independent antigens. Cellular Immunology, 43, 202.CrossRefGoogle ScholarPubMed
Moqbel, R. (1976) Studies on the host-parasite relationship of Strongyloides ratti in rats. Ph.D. Thesis, University of LondonGoogle Scholar
Moss, G. D. (1972) The effect of cortisone acetate treatment on the growth of Hymenolepis microstoma in mice. Parasitology, 64, 311–320.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. (1965) Use of cortisone derivatives to inhibit resistance to Nippostrongylus brasiliensis and to study the fate of parasites in resistant hosts. Parasitology, 55, 723–730.CrossRefGoogle Scholar
Snedecor, G. W. & Cochran, W.G. (1967) Statistical Methods, 6th Edition. Iowa State University Press: Iowa, USA.Google Scholar
Smyth, J. D. (1969) Parasites as biological models. Parasitology, 59, 73–91.CrossRefGoogle ScholarPubMed
Wakelin, D. (1969) Studies on the immunity of albino mice to Trichuris muris. The stimulation of immunity by chemically-abbreviated infections. Parasitology, 59, 549–555.CrossRefGoogle ScholarPubMed
Wakelin, D. & Denham, D.A. (1983) The immune response. In: Trichinella and Trichinosis (editor Campbell, W. C.), pp. 265–308. Plenum Press: New York.CrossRefGoogle Scholar
Wakelin, D. & Selby, G.R. (1974) The induction of immunological tolerance to the parasitic nematode Trichuris muris in cortisone-treated mice. Immunology, 26, 1–10.Google Scholar
Wassom, D. L., Dewitt, C. W. & Grundmann, A.W. (1974) Immunity to Hymenolepis citelli by Peromyscus maniculatus: genetic control and ecological implications. Journal of Parasitology 60 47–52CrossRefGoogle ScholarPubMed
Wassom, D. L., Guss, V. M. & Grundmann, A.W. (1973) Host resistance in a natural host-parasite system. Resistance to Hymenolepis citelli by Peromyscus maniculatus. Journal of Parasitology, 59, 117–121.CrossRefGoogle Scholar
Weinmann, C. J. (1966) Immunity mechanisms in cestode infections. In: Biology of Parasites (editor Soulsby, E. J. L.), pp. 301–320. Academic Press: New York.Google Scholar
Williams, J. F. (1979) Recent advances in the immunology of cestode infections. Journal of Parasitology, 65, 337–349CrossRefGoogle ScholarPubMed