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Humoral and cellular response to infection with Echinostoma revolutum in the golden hamster, Mesocricetus auratus

Published online by Cambridge University Press:  05 June 2009

J. Mabus ,
J. E. Huffman  and
B. Fried
J. Mabus
Affiliation:
Department of Zoology and Physiology, Parasitology Laboratory, Rutgers-The State University, Newark, New Jersey 07102, USA Department of Biology, Lafayette College, Easton, Pennsylvania 18042, USA
J. E. Huffman*
Affiliation:
Department of Zoology and Physiology, Parasitology Laboratory, Rutgers-The State University, Newark, New Jersey 07102, USA Department of Biology, Lafayette College, Easton, Pennsylvania 18042, USA
B. Fried
Affiliation:
Department of Zoology and Physiology, Parasitology Laboratory, Rutgers-The State University, Newark, New Jersey 07102, USA Department of Biology, Lafayette College, Easton, Pennsylvania 18042, USA
*
*Author for correspondence.
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Abstract

Laboratory hamsters (Mesocricetus auratus) were infected with Echinostoma revolutum (Trematoda). Immunoelectrophoretic studies of hamster serum showed no demonstrable antibody response to E. revolutum. Histopathologic examination of intestinal tissue of infected hamsters showed erosion of intestinal villi and lymphocytic infiltration as the primary host response. Spleens from infected hamsters were hyperplastic during the first 3 weeks of infection and atrophic from 4 to 8 weeks postinfection. Hamsters were unable to acquire a resistance to E. revolutum infection. Lack of resistance was demonstrated in hamsters where the parasite infection was no longer detected based on the absence of eggs in the faeces; these hamsters were then reinfected. Hamsters treated with the anthelmintic oxyclozanide were also reinfected with E. revolutum.

Keywords

Echinostoma revolutumMesocricetus auratusimmune response
Type
Research Papers
Information
Journal of Helminthology , Volume 62 , Issue 2 , June 1988 , pp. 127 - 132
Copyright
Copyright © Cambridge University Press 1988

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