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Efficacy of ivermectin against Parastrongylus malaysiensis infection in rats

Published online by Cambridge University Press:  05 June 2009

S. Ambu ,
J. W. Mak  and
C. S. Ng
S. Ambu
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
J. W. Mak
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
C. S. Ng
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
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Abstract

The efficacy of ivermectin on experimental infections of P. malaysiensis in rats was determined. Ivermectin was 99·4% and 97·9% effective at a dosage of 400 mcg and 800 mcg respectively at seven days post-infection. The same two dosages of ivermectin when given at 14 days post infection had an efficacy of 100%. However, as an adulticide it had only 40·7% efficacy. Ivermectin may therefore be useful for the treatment of parastrongyliasis due to the larval stages of the worm which can cause significant pathology in man and animals.

Keywords

Parastrongylus malaysiensisrativermectinchemotherapyNematoda
Type
Research Article
Information
Journal of Helminthology , Volume 66 , Issue 4 , December 1992 , pp. 293 - 296
Copyright
Copyright © Cambridge University Press 1992

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References

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