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Effects of the anthelmintics clorsulon, rafoxanide, mebendazole and arprinocid on Echinostoma caproni in ICR mice

Published online by Cambridge University Press:  05 June 2009

K. Maurer ,
M. Decere  and
B. Fried
K. Maurer
Affiliation:
Department of Biology, Lafayette College, Eston, Pennsylvania 18042, USA
M. Decere
Affiliation:
Department of Biology, Lafayette College, Eston, Pennsylvania 18042, USA
B. Fried*
Affiliation:
Department of Biology, Lafayette College, Eston, Pennsylvania 18042, USA
*
*Author for correspondence
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Abstract

Female ICR mice, 5 to 6 weeks old, were exposed by stomach tube to 25 metacercarial cysts of Echinostoma caproni per mouse. At 14 days post-exposure, mice were fed by stomach tube clorsulon (1000 mg/kg, 25 mg/kg, 500 mg/kg and 100 mg/kg) or rafoxanide (50 mg/kg, 25 mg/kg and 5 mg/kg) dissolved in dimethy lsulphoxide (DMSO) carrier and mebendazole (1000mg/kg and 500 mg/kg) or arprinocid (100 mg/kg and 50 mg/kg) suspended in a2:1 polyethylene glycol (PEG)/DMSO carrier. All drugs were obtained from Meerck In. (Rahway, New Jersey, USA) and only single dose regimes were used. Experimentally infected mice that served as controls received either DMSO or 2:1 PEG/DMSO carriers or were not given the carrier. Mice were necropsied 15v, 16, 18 and 20 days post-exposure to worms. Doses of 100 mg/kg of clorsulon and 50 mg/kg of rafoxanide were 100% effective in eliminating the echinostomes on day 1 post-administration of the anthelmintics. Mebendazole and arprinocid were ineffection in eliminating worms at 1 or 2 days post drug daministration.

Type
Research Note
Information
Journal of Helminthology , Volume 69 , Issue 4 , December 1995 , pp. 373 - 374
Copyright
Copyright © Cambridge University Press 1995

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